U-18666A

Suppliers

Names

[ Name ]:
U-18666A

[Synonym ]:
Androst-5-en-17-one, 3-[2- (diethylamino)ethoxy]-, hydrochloride, (3β)-
(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride (1:1)
Androst-5-en-17-one, 3β-(2-(diethylamino)ethoxy)-, hydrochloride (8CI)
Androst-5-en-17-one, 3β-[2- (diethylamino)ethoxy]-, hydrochloride
Androst-5-en-17-one, 3-(2-(diethylamino)ethoxy)-, hydrochloride, (3β)-
Androst-5-en-17-one, 3-[2-(diethylamino)ethoxy]-, (3β)-, hydrochloride (1:1)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₄₂ClNO₂

[ Molecular Weight ]:
424.060

[ Exact Mass ]:
423.290405

[ PSA ]:
29.54000

[ LogP ]:
6.04730

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.

Autophagy 10(7) , 1241-55, (2014)

Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazol...

Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.

J. Biol. Chem. 288(5) , 3136-52, (2013)

Cathepsin D is an aspartyl protease that plays a crucial role in normal cellular functions and in a variety of neurodegenerative disorders, including Niemann-Pick type C (NPC) disease, which is charac...

Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells.

PLoS ONE 7 , e30051, (2012)

A variety of intercalating amphipaths increase the chemical activity of plasma membrane cholesterol. To test whether intracellular cholesterol can be similarly activated, we examined NPC1 and NPC2 fib...

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