AGK2

Suppliers

Names

[ Name ]:
AGK2

[Synonym ]:
ARC 239 dihydrochloride
(2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
(2E)-2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-(5-quinolinyl)acrylamide
AGK2
2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-, (2E)-
(2E)-2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-(quinolin-5-yl)acrylamide
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
675.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₁₃Cl₂N₃O₂

[ Molecular Weight ]:
434.274

[ Flash Point ]:
362.1±31.5 °C

[ Exact Mass ]:
433.038483

[ PSA ]:
78.92000

[ LogP ]:
5.39

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.718

[ Storage condition ]:
Room temp

[ Water Solubility ]:
DMSO: soluble2mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity.

Eur. J. Med. Chem. 92 , 145-55, (2015)

Sirtuins are protein deacylases with regulatory roles in metabolism and stress response. Functionalized tetrahydro-1H-pyrido[4,3-b]indoles were identified as preferential sirtuin 2 inhibitors, with in...

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages.

Biochem. Biophys. Res. Commun. 450(4) , 1363-9, (2014)

SIRT2 is a NAD(+)-dependent deacetylases and associated with numerous processes such as infection, carcinogenesis, DNA damage and cell cycle regulation. However, the role of SIRT2 in inflammatory proc...

Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging.

EMBO J. 33(12) , 1321-40, (2014)

Neural stem/progenitor cell (NSPC) proliferation and self-renewal, as well as insult-induced differentiation, decrease markedly with age. The molecular mechanisms responsible for these declines remain...