4-Chloro-5-sulfamoylanthranilic Acid
Names
[ CAS No. ]:
3086-91-7
[ Name ]:
4-Chloro-5-sulfamoylanthranilic Acid
[Synonym ]:
4-Chloro-5-sulfamoylanthranilic acid
2-AMINO-5-AMINOSULFONYL-4-CHLOROBENZOIC ACID
4-chloro-5-sulphamoyl anthranilic acid
Desfurylmethylfurosemide
Saluamine
2-amino-4-chloro-5-sulfamoyl-benzoic acid
Furosemide Related Compound B
EINECS 221-408-7
4-chloro-5-sulfamoyl-anthranilic acid
4-Chloro-5-sulfanilanthranilic acid
Chemical & Physical Properties
[ Density]:
1.726g/cm3
[ Boiling Point ]:
549.2ºC at 760mmHg
[ Melting Point ]:
267°C (dec.) (lit.)
[ Molecular Formula ]:
C7H7ClN2O4S
[ Molecular Weight ]:
250.65900
[ Flash Point ]:
286ºC
[ Exact Mass ]:
249.98200
[ PSA ]:
131.86000
[ LogP ]:
2.63010
[ Index of Refraction ]:
1.665
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P305 + P351 + P338
[ Hazard Codes ]:
N
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2935009090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2935009090
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
Articles
Acta Pharmacol. Toxicol. (Copenh.) 49(3) , 223-9, (1981)
Three principles for the use of HPLC with spectrophotometric detection to determine the concentration of furosemide and of 4-chloro-5-sulfamoyl anthranilic acid (CSA) were studied. A reversed phase mi...
Acta Pharmacol. Toxicol. (Copenh.) 47(3) , 202-7, (1980)
The percentual binding of furosemide (5 micrograms/ml) was slightly but significantly lower in serum from elderly patients than in serum from normal blood donors (96.5 +/- 0.7 versus 97.9 +/- 0.3). A ...
Nephron 53(2) , 138-41, (1989)
Furosemide is known to potentiate gentamicin nephrotoxicity. The mechanism of potentiation is unclear. In our previous studies, we demonstrated that furosemide enhanced gentamicin accumulation in rabb...