4-Chloro-5-sulfamoylanthranilic Acid
4-Chloro-5-sulfamoylanthranilic Acid structure
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Common Name | 4-Chloro-5-sulfamoylanthranilic Acid | ||
|---|---|---|---|---|
| CAS Number | 3086-91-7 | Molecular Weight | 250.65900 | |
| Density | 1.726g/cm3 | Boiling Point | 549.2ºC at 760mmHg | |
| Molecular Formula | C7H7ClN2O4S | Melting Point | 267°C (dec.) (lit.) | |
| MSDS | N/A | Flash Point | 286ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Summary: 4-Chloro-5-sulfamoylanthranilic Acid, 2-amino-4-chloro-5-sulfamoylbenzoic acid, Chinese name: 4-氯-5-氨磺酰邻氨基苯甲酸, CAS number: 3086-91-7, molecular formula: C7H7ClN2O4S, molecular weight: 250.66. Appearance: solid, melting point: 267°C, density: 1.726g/cm3. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 2-amino-4-chloro-5-sulfamoylbenzoic acid |
|---|---|
| Synonym | More Synonyms |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.726g/cm3 |
|---|---|
| Boiling Point | 549.2ºC at 760mmHg |
| Melting Point | 267°C (dec.) (lit.) |
| Molecular Formula | C7H7ClN2O4S |
| Molecular Weight | 250.65900 |
| Flash Point | 286ºC |
| Exact Mass | 249.98200 |
| PSA | 131.86000 |
| LogP | 2.63010 |
| Index of Refraction | 1.665 |
| InChIKey | QQLJBZFXGDHSRU-UHFFFAOYSA-N |
| SMILES | Nc1cc(Cl)c(S(N)(=O)=O)cc1C(=O)O |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | N |
| RIDADR | NONH for all modes of transport |
| HS Code | 2935009090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~51%
4-Chloro-5-sulf... CAS#:3086-91-7 |
| Literature: NITROMED, INC. Patent: WO2006/55542 A2, 2006 ; Location in patent: Page/Page column 69-70 ; WO 2006/055542 A2 |
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~%
4-Chloro-5-sulf... CAS#:3086-91-7 |
| Literature: Journal of the American Chemical Society, , vol. 81, p. 5508 Journal of the American Chemical Society, , vol. 82, p. 2731,2733,2734 US2952680 , ; US2910488 , ; |
|
~%
4-Chloro-5-sulf... CAS#:3086-91-7 |
| Literature: Journal of the American Chemical Society, , vol. 81, p. 5508 Journal of the American Chemical Society, , vol. 82, p. 2731,2733,2734 US2952680 , ; US2910488 , ; |
|
~%
4-Chloro-5-sulf... CAS#:3086-91-7 |
| Literature: Journal of the American Chemical Society, , vol. 81, p. 5508 Journal of the American Chemical Society, , vol. 82, p. 2731,2733,2734 |
|
~29%
4-Chloro-5-sulf... CAS#:3086-91-7 |
| Literature: Tetrahedron, , vol. 67, # 49 p. 9518 - 9521 |
![N-[4-(AMINOSULFONYL)-5-CHLORO-2-METHYLPHENYL]ACETAMIDE structure](https://image.chemsrc.com/caspic/022/17560-53-1.png)
![4-chloro-2-[(2,5-dimethoxy-2,5-dihydro-furan-2-ylmethyl)-amino]-5-sulfamoyl-benzoic acid structure](https://image.chemsrc.com/caspic/316/1351169-05-5.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
|---|---|
| DownStream 1 | |
CAS#:34121-17-0This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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The use of HPLC to elucidate the metabolism and urinary excretion of furosemide and its metabolic products.
Acta Pharmacol. Toxicol. (Copenh.) 49(3) , 223-9, (1981) Three principles for the use of HPLC with spectrophotometric detection to determine the concentration of furosemide and of 4-chloro-5-sulfamoyl anthranilic acid (CSA) were studied. A reversed phase mi... |
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The binding of furosemide to serum proteins in elderly patients: displacing effect of phenprocoumon.
Acta Pharmacol. Toxicol. (Copenh.) 47(3) , 202-7, (1980) The percentual binding of furosemide (5 micrograms/ml) was slightly but significantly lower in serum from elderly patients than in serum from normal blood donors (96.5 +/- 0.7 versus 97.9 +/- 0.3). A ... |
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Furosemide accelerates gentamicin accumulation in cultured renal cells (LLC-PK1 cells).
Nephron 53(2) , 138-41, (1989) Furosemide is known to potentiate gentamicin nephrotoxicity. The mechanism of potentiation is unclear. In our previous studies, we demonstrated that furosemide enhanced gentamicin accumulation in rabb... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 4-Chloro-5-sulfamoylanthranilic acid |
| 2-AMINO-5-AMINOSULFONYL-4-CHLOROBENZOIC ACID |
| 4-chloro-5-sulphamoyl anthranilic acid |
| Desfurylmethylfurosemide |
| Saluamine |
| 2-amino-4-chloro-5-sulfamoyl-benzoic acid |
| Furosemide Related Compound B |
| EINECS 221-408-7 |
| 4-chloro-5-sulfamoyl-anthranilic acid |
| 4-Chloro-5-sulfanilanthranilic acid |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of 2-amino-4-chloro-5-sulfamoylbenzoic acid? |
| A: Polar surface area (PSA) of 2-amino-4-chloro-5-sulfamoylbenzoic acid is 131.86000. |
| Q: What is the boiling point of 2-amino-4-chloro-5-sulfamoylbenzoic acid? |
| A: Boiling point of 2-amino-4-chloro-5-sulfamoylbenzoic acid is 549.2ºC at 760mmHg. |
| Q: What is the InChIKey of 2-amino-4-chloro-5-sulfamoylbenzoic acid? |
| A: InChIKey of 2-amino-4-chloro-5-sulfamoylbenzoic acid is QQLJBZFXGDHSRU-UHFFFAOYSA-N. |
| Q: What is the melting point of 2-amino-4-chloro-5-sulfamoylbenzoic acid? |
| A: Melting point of 2-amino-4-chloro-5-sulfamoylbenzoic acid is 267°C (dec.) (lit.). |
| Q: What English synonyms does 2-amino-4-chloro-5-sulfamoylbenzoic acid have? |
| A: English synonyms of 2-amino-4-chloro-5-sulfamoylbenzoic acid: 4-Chloro-5-sulfamoylanthranilic acid, 2-AMINO-5-AMINOSULFONYL-4-CHLOROBENZOIC ACID, 4-chloro-5-sulphamoyl anthranilic acid, Desfurylmethylfurosemide, Saluamine, 2-amino-4-chloro-5-sulfamoyl-benzoic acid, Furosemide Related Compound B, EINECS 221-408-7, 4-chloro-5-sulfamoyl-anthranilic acid, 4-Chloro-5-sulfanilanthranilic acid. |
| Q: What is the LogP of 2-amino-4-chloro-5-sulfamoylbenzoic acid? |
| A: LogP of 2-amino-4-chloro-5-sulfamoylbenzoic acid is 2.63010. |
| Q: What is the molecular weight of 2-amino-4-chloro-5-sulfamoylbenzoic acid? |
| A: Molecular weight of 2-amino-4-chloro-5-sulfamoylbenzoic acid is 250.65900. |
| Q: What are the upstream materials of 2-amino-4-chloro-5-sulfamoylbenzoic acid? |
| A: Related upstream materials(CAS) of 2-amino-4-chloro-5-sulfamoylbenzoic acid: 54-31-9;17560-54-2;17560-53-1;5900-55-0;67-56-1. |
| Q: What are the downstream products of 2-amino-4-chloro-5-sulfamoylbenzoic acid? |
| A: Related downstream products(CAS) of 2-amino-4-chloro-5-sulfamoylbenzoic acid: 34121-17-0. |
| Q: What is the SMILES notation of 2-amino-4-chloro-5-sulfamoylbenzoic acid? |
| A: SMILES notation of 2-amino-4-chloro-5-sulfamoylbenzoic acid is Nc1cc(Cl)c(S(N)(=O)=O)cc1C(=O)O. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |