ibuprofen sodium salt

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Names

[ Name ]:
ibuprofen sodium salt

[Synonym ]:
EINECS 250-477-6
Sodium ibuprofen
sodium 2-[4-(2-methylpropyl)phenyl]propanoate
p-Isobutylhydratropic acid sodium salt
2-(4'-isobutylphenyl)propionic acid,sodium salt
Sodium 2-(4-isobutylphenyl)propionate
Hydratropic acid,p-isobutyl-,sodium salt
Ibuprofen sodium salt
Ibuprofen sodium
(RS)-ibuprofen sodium
2-(p-isobutylphenyl)propionic acid sodium salt

Chemical & Physical Properties

[ Density]:
1.029g/cm3

[ Boiling Point ]:
319.6ºC at 760 mmHg

[ Melting Point ]:
75-77ºC

[ Molecular Formula ]:
C₁₃H₁₇NaO₂

[ Molecular Weight ]:
228.26300

[ Flash Point ]:
216.7ºC

[ Exact Mass ]:
228.11300

[ PSA ]:
40.13000

[ LogP ]:
1.73850

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents

[ Water Solubility ]:
H2O: 100 mg/mL, may be clear to slightly hazy

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MU6641000

CHEMICAL NAME :: Hydratropic acid, p-isobutyl-, sodium salt

CAS REGISTRY NUMBER :: 31121-93-4

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H17-O2.Na

MOLECULAR WEIGHT :: 228.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 38,238,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MU6641000

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

The advantages and limitations of the analgesics available for control of postoperative pain after a dental procedure.

SAAD Dig. 29 , 70-81, (2013)

Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.

PLoS Genet. 10(12) , e1004860, (2014)

The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanist...

Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen.

J. Pharmacol. Exp. Ther. 351(1) , 61-6, (2014)

Esterase hydrolysis of drugs can accelerate their elimination, thereby limiting their efficacy. Polyethylene glycol (PEG) covalently attached to drugs (pegylation) is known to improve the efficiency o...