Flubendazole

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Names

[ Name ]:
Flubendazole

[Synonym ]:
Biovermin
Methyl (5-(4-fluorobenzoyl)-1H-benzo[d]imidazol-2-yl)carbamate
Flubendazole
[5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamic Acid Methyl Ester
Flutelmium
EINECS 250-624-4
FLUVERNAL
Flubendazol,Flumoxanal,Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
[5-(4-Fluorobenzoyl)-1H-benzimidazol-2-yl]carbamic Acid Methyl Ester
Flubenol
fluvermal
Flumoxal
Carbamic acid, N-[5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-, methyl ester
Flumoxanal (Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
methyl {6-[(4-fluorophenyl)carbonyl]-1H-benzimidazol-2-yl}carbamate
Flubenvet
Carbamicacid, [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-methylester
Methyl {5-[(4-fluorophenyl)carbonyl]-1H-benzimidazol-2-yl}carbamate
MFCD00871999
FLUMOXANAL
Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
Methyl [5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamate
5-(p-Fluorobenzoyl)-2-benzimidazolecarbamic Acid Methyl Ester
FLUMOXANE
Methyl-{5-[(4-fluorphenyl)carbonyl]-1H-benzimidazol-2-yl}carbamat
carbamic acid, [6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-, methyl ester

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
290°C

[ Molecular Formula ]:
C₁₆H₁₂FN₃O₃

[ Molecular Weight ]:
313.283

[ Exact Mass ]:
313.086273

[ PSA ]:
84.08000

[ LogP ]:
3.05

[ Index of Refraction ]:
1.685

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6497500

CHEMICAL NAME :: 2-Benzimidazolecarbamic acid, 5-(p-fluorobenzoyl)-, methyl ester

CAS REGISTRY NUMBER :: 31430-15-6

LAST UPDATED :: 199410

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C16-H12-F-N3-O3

MOLECULAR WEIGHT :: 313.31

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GVR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 320 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1280 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - gastrointestinal system

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

REFERENCE :: PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975- Volume(issue)/page/year: 340E,225,1990

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
DD6497500

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs.

Expert Rev. Anti. Infect. Ther. 9(5) , 497-501, (2011)

Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions.

Int. J. Pharm. 453(2) , 343-50, (2013)

This work investigates the flocculation effect of polyethylene glycol (PEG) on typical aqueous dispersions, such as O/W emulsions and solid/liquid suspensions. Hereby, sunflower oil and flubendazole w...

Transfer of flubendazole and tylosin from feed at cross-contamination levels to various poultry matrices.

Poult. Sci. 91(9) , 2351-60, (2012)

Residues of veterinary drugs and feed additives used extensively in animal husbandry are sometimes found in edible matrices. In this study, broilers received experimental feed, containing either flube...

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