Flubendazole

Modify Date: 2024-01-02 18:53:59

Flubendazole Structure
Flubendazole structure
Common Name Flubendazole
CAS Number 31430-15-6 Molecular Weight 313.283
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C16H12FN3O3 Melting Point 290°C
MSDS Chinese USA Flash Point N/A

 Use of Flubendazole


Flubendazole is a potent broad spectrum anthelmintic.Target: AntiparasiticFlubendazole is an anthelmintic. It is also available for human use to treat worm infections[1].

 Names

Name flubendazole
Synonym More Synonyms

 Flubendazole Biological Activity

Description Flubendazole is a potent broad spectrum anthelmintic.Target: AntiparasiticFlubendazole is an anthelmintic. It is also available for human use to treat worm infections[1].
Related Catalog
References

[1]. http://www.patentstorm.us/patents/5824336/description.html

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 290°C
Molecular Formula C16H12FN3O3
Molecular Weight 313.283
Exact Mass 313.086273
PSA 84.08000
LogP 3.05
Index of Refraction 1.685
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD6497500
CHEMICAL NAME :
2-Benzimidazolecarbamic acid, 5-(p-fluorobenzoyl)-, methyl ester
CAS REGISTRY NUMBER :
31430-15-6
LAST UPDATED :
199410
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C16-H12-F-N3-O3
MOLECULAR WEIGHT :
313.31
WISWESSER LINE NOTATION :
T56 BM DNJ CMVO1 GVR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>2560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
320 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1280 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - gastrointestinal system

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
REFERENCE :
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975- Volume(issue)/page/year: 340E,225,1990

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
RTECS DD6497500
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles29

More Articles
Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs.

Expert Rev. Anti. Infect. Ther. 9(5) , 497-501, (2011)

Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions.

Int. J. Pharm. 453(2) , 343-50, (2013)

This work investigates the flocculation effect of polyethylene glycol (PEG) on typical aqueous dispersions, such as O/W emulsions and solid/liquid suspensions. Hereby, sunflower oil and flubendazole w...

Transfer of flubendazole and tylosin from feed at cross-contamination levels to various poultry matrices.

Poult. Sci. 91(9) , 2351-60, (2012)

Residues of veterinary drugs and feed additives used extensively in animal husbandry are sometimes found in edible matrices. In this study, broilers received experimental feed, containing either flube...

 Synonyms

Biovermin
Methyl (5-(4-fluorobenzoyl)-1H-benzo[d]imidazol-2-yl)carbamate
Flubendazole
[5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamic Acid Methyl Ester
Flutelmium
EINECS 250-624-4
FLUVERNAL
Flubendazol,Flumoxanal,Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
[5-(4-Fluorobenzoyl)-1H-benzimidazol-2-yl]carbamic Acid Methyl Ester
Flubenol
fluvermal
Flumoxal
Carbamic acid, N-[5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-, methyl ester
Flumoxanal (Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
methyl {6-[(4-fluorophenyl)carbonyl]-1H-benzimidazol-2-yl}carbamate
Flubenvet
Carbamicacid, [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-methylester
Methyl {5-[(4-fluorophenyl)carbonyl]-1H-benzimidazol-2-yl}carbamate
MFCD00871999
FLUMOXANAL
Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
Methyl [5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamate
5-(p-Fluorobenzoyl)-2-benzimidazolecarbamic Acid Methyl Ester
FLUMOXANE
Methyl-{5-[(4-fluorphenyl)carbonyl]-1H-benzimidazol-2-yl}carbamat
carbamic acid, [6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-, methyl ester
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