D-Isoleucine

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Names

[ CAS No. ]:
319-78-8

[ Name ]:
D-Isoleucine

[Synonym ]:
(R)-Isoleucine
D-Isoleucine
EINECS 206-269-2
D-(-)-Isoleucine
H-D-Allo-Ile-OH
MFCD00064221
H-D-Ile-OH
(2R,3R)-2-Amino-3-methylpentanoic acid
(2R (3R)-2-Amino-3-methylpentanoic acid

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
225.8±23.0 °C at 760 mmHg

[ Melting Point ]:
272-274ºC

[ Molecular Formula ]:
C6H13NO2

[ Molecular Weight ]:
131.173

[ Flash Point ]:
90.3±22.6 °C

[ Exact Mass ]:
131.094635

[ PSA ]:
63.32000

[ LogP ]:
0.73

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.463

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NR4700000
CHEMICAL NAME :
Isoleucine, D-
CAS REGISTRY NUMBER :
319-78-8
BEILSTEIN REFERENCE NO. :
1721793
LAST UPDATED :
199803
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H13-N-O2
MOLECULAR WEIGHT :
131.20
WISWESSER LINE NOTATION :
QVYZY2&1 -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6822 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NR4700000

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (3S)-3-Methyl-2-oxopentanoic acid
  • 2-Amino-3-methylenpentansaeure
  • 2-Ethacrolein
  • 2-Methylbutanal
  • 2-Amino-4-methylpentanoic acid
  • D-Isoleucine
  • 4-butan-2-ylidene-2-phenyl-1,3-oxazol-5-one

DownStream

  • chloroacetyl-dl-isoleucine
  • Pentanoicacid, 2-bromo-3-methyl-
  • (3S)-3-methylpentanoic acid
  • L-Isoleucine
  • D-Isoleucine
  • (S)-2-methylbutyric acid
  • 4-butan-2-yl-2-(trifluoromethyl)-2H-1,3-oxazol-5-one
  • 2-Methylbutanal
  • 2-METHYLBUTYLAMINE
  • 3,6-di-sec-butyl-piperazine-2,5-dione

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Simultaneous determination of 18 D-amino acids in rat plasma by an ultrahigh-performance liquid chromatography-tandem mass spectrometry method: application to explore the potential relationship between Alzheimer's disease and D-amino acid level alterations.

Anal. Bioanal. Chem 408 , 141-50, (2016)

D-Amino acids are increasingly being recognized as important signaling molecules, and abnormal levels of D-amino acids have been implicated in the pathogenesis of Alzheimer's disease. To evaluate the ...

A Highly Stable D-Amino Acid Oxidase of the Thermophilic Bacterium Rubrobacter xylanophilus.

Appl. Environ. Microbiol. 80(23) , 7219-29, (2015)

d-Amino acid oxidase (DAO) is a biotechnologically attractive enzyme that can be used in a variety of applications, but its utility is limited by its relatively poor stability. A search of a bacterial...

Combination of amino acids reduces pigmentation in B16F0 melanoma cells.

Biol. Pharm. Bull. 30 , 677-681, (2007)

Amino acids, the building blocks of proteins, play significant roles in numerous physiological events in mammals. As the effects of amino acids on melanogenesis have yet to be demonstrated, the presen...


More Articles

Related Compounds

  • Boc-D-isoleucine
  • CBZ-D-Isoleucine
  • Boc-D-Isoleucine
  • allo-D-isoleucine
  • Fmoc-D-isoleucine
  • D-Isoleucine,2-methyl
  • 6-Oxo-4-(4-phenylpiperazin-1-yl)-1,6-dihydropyrimidine-5-carbaldehyde
  • 2-(Azetidin-1-yl)pyrimidine-5-carbaldehyde
  • 4-(Azetidin-1-yl)-3,5-difluorobenzaldehyde
  • 6-(Azetidin-1-yl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde
  • 4-Bromo-N,3,5-trimethylbenzene-1-sulfonamide
  • 2,6-Dibromo-n-ethylbenzene-1-sulfonamide
  • 2-(2,4,5-Trifluorophenyl)propanenitrile
  • 4-(Azetidin-1-yl)-6-chloro-2-methylpyrimidine-5-carbaldehyde
  • 4-(Azetidin-1-yl)thiophene-2-carbaldehyde
  • 4-(Azetidin-1-yl)-3-fluorobenzaldehyde
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