D-Isoleucine

Modify Date: 2024-01-02 09:30:11

D-Isoleucine Structure
D-Isoleucine structure
 Common Name D-Isoleucine
CAS Number 319-78-8 Molecular Weight 131.173
Density 1.0±0.1 g/cm3 Boiling Point 225.8±23.0 °C at 760 mmHg
Molecular Formula C6H13NO2 Melting Point 272-274ºC
MSDS Chinese USA Flash Point 90.3±22.6 °C

 Use of D-Isoleucine


D-Isoleucine ((R)-Isoleucine), an isoleucine stereoisomer, is a selective activator of Asc-1 antiporter, which enhances long-term potentiation at the hippocampal CA1-CA3 via release of endogenous D-serine[1].

 Names

Name D-isoleucine
Synonym More Synonyms

 D-Isoleucine Biological Activity

Description D-Isoleucine ((R)-Isoleucine), an isoleucine stereoisomer, is a selective activator of Asc-1 antiporter, which enhances long-term potentiation at the hippocampal CA1-CA3 via release of endogenous D-serine[1].
Related Catalog
References

[1]. Rosenberg D, et, al. Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity. J Neurosci. 2013 Feb 20;33(8):3533-44.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 225.8±23.0 °C at 760 mmHg
Melting Point 272-274ºC
Molecular Formula C6H13NO2
Molecular Weight 131.173
Flash Point 90.3±22.6 °C
Exact Mass 131.094635
PSA 63.32000
LogP 0.73
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.463

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NR4700000
CHEMICAL NAME :
Isoleucine, D-
CAS REGISTRY NUMBER :
319-78-8
BEILSTEIN REFERENCE NO. :
1721793
LAST UPDATED :
199803
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H13-N-O2
MOLECULAR WEIGHT :
131.20
WISWESSER LINE NOTATION :
QVYZY2&1 -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6822 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956

 Safety Information

Hazard Codes Xn
Risk Phrases R40
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NR4700000
HS Code 2922499990

 Synthetic Route

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles6

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Amino acids, the building blocks of proteins, play significant roles in numerous physiological events in mammals. As the effects of amino acids on melanogenesis have yet to be demonstrated, the presen...

 Synonyms

(R)-Isoleucine
D-Isoleucine
EINECS 206-269-2
D-(-)-Isoleucine
H-D-Allo-Ile-OH
MFCD00064221
H-D-Ile-OH
(2R,3R)-2-Amino-3-methylpentanoic acid
(2R (3R)-2-Amino-3-methylpentanoic acid
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