Triflusal
Suppliers
Names
[ CAS No. ]:
322-79-2
[ Name ]:
Triflusal
[Synonym ]:
Triflusal
2-(acetyloxy)-4-(trifluoromethyl)benzoic acid
α,α,α-Trifluoro-2,4-cresotic Acid Acetate
2-Acetoxy-4-trifluoromethylbenzoic acid
EINECS 206-297-5
Triflusalum [INN-Latin]
2-Acetoxy-4-trifluoromethylbenzoicacid
Benzoic acid, 2-(acetyloxy)-4-(trifluoromethyl)-
Triflusal [INN]
2-Acetoxy-4-trifluormethyl-benzoesaeure
2-Acetoxy-4-(trifluoromethyl)benzoic acid
2-Acetyloxy-4-trifluoromethylbenzoic acid
UR 1501
MFCD00866793
Disgren
Triflux
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
316.0±42.0 °C at 760 mmHg
[ Melting Point ]:
115 °C
[ Molecular Formula ]:
C10H7F3O4
[ Molecular Weight ]:
248.155
[ Flash Point ]:
144.9±27.9 °C
[ Exact Mass ]:
248.029648
[ PSA ]:
63.60000
[ LogP ]:
2.90
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.484
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GP4250000
- CHEMICAL NAME :
- 2,4-Cresotic acid, alpha,alpha,alpha-trifluoro-, acetate
- CAS REGISTRY NUMBER :
- 322-79-2
- BEILSTEIN REFERENCE NO. :
- 2945374
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C10-H7-F3-O4
- MOLECULAR WEIGHT :
- 248.17
- WISWESSER LINE NOTATION :
- FXFFR DVQ COV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 402 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 217 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 228 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 437 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 380 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,225,1978
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H317-H319-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22-36/37/38-43
[ Safety Phrases ]:
26-36/37
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
GP4250000
[ HS Code ]:
2918990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918990090
[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Rev. Esp. Cardiol. 62(9) , 992-1000, (2009)
In the NASPEAF (National Study for Prevention of Embolism in Atrial Fibrillation) trial, combination therapy with an anticoagulant and an antiplatelet was more effective than anticoagulation alone in ...
Comb. Chem. High Throughput Screen 13(7) , 569-77, (2010)
The electrochemical behavior of triflusal (TRF) and aspirin (ASA), before and after hydrolysis in water and in alkaline medium using two different electrode surfaces, glassy carbon and boron doped dia...
Expert Opin. Drug Metab. Toxicol. 7(12) , 1471-9, (2011)
An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compa...