H-Glu(OtBu)-OtBu.HCl

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Names

[ Name ]:
H-Glu(OtBu)-OtBu.HCl

[Synonym ]:
H-Glu(OtBu)-OtBu·HCl
H-Glu(OtBu)-OtBuï¿½ï¿½HCl
L-glutamic acid di-t-butyl ester hydrochloride
MFCD00058003
Di-tert-butyl L-glutamate hydrochloride (1:1)
L-Glutamic acid, bis(1,1-dimethylethyl) ester, hydrochloride (1:1)
H-Glu(OtBu)-OtBu,HCl
H-L-Glu(OtBu)-OtBu*HCl
L-Glutamic acid di-tert
L-Glutamic Acid di-Tert-Butyl Ester Hydrochloride
Bis(2-methyl-2-propanyl) L-glutamate hydrochloride (1:1)
(S)-Di-tert-butyl 2-aminopentanedioate hydrochloride
H-Glu(OtBu)-OtBu.HCl
L-Glutamic acid di-tert-butylester hydrochloride

Chemical & Physical Properties

[ Density]:
1.02g/cm3

[ Boiling Point ]:
311.1ºC at 760 mmHg

[ Melting Point ]:
60 to 75ºC

[ Molecular Formula ]:
C₁₃H₂₆ClNO₄

[ Molecular Weight ]:
295.803

[ Flash Point ]:
78.1ºC

[ Exact Mass ]:
295.155029

[ PSA ]:
78.62000

[ LogP ]:
3.27960

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0880000

CHEMICAL NAME :: L-Glutamic acid, bis(1,1-dimethylethyl)ester, hydrochloride

CAS REGISTRY NUMBER :: 32677-01-3

LAST UPDATED :: 198703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H25-N-O4.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 7,275,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 7,275,1985

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MA0880000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

L-glutamic acid
H-Glu(OtBu)-OH
H-Glu-OtBu
N-[(4-Methylphenyl)sulfonyl]-L-glutamic acid
cmda
4-N-bis(2-chloroethyl)aminobenzoylglutamic acid
Bis(2-methyl-2-propanyl) N-[(benzyloxy)carbonyl]-L-glutamate
ditert-butyl 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioate

Articles

Synthesis and biological activity of analogues of the C-terminal hexapeptide of substance P with modifications at glutaminyl and methioninyl residues. Structure-activity studies.

Int. J. Pept. Protein Res. 40 , 395-400, (1992)

Analogues of [Orn6]-SP6-11 have been synthesized in which the methionyl residue is replaced by glutamine gamma-carboxamide substituted derivatives. These analogues where tested in three in vitro prepa...

Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.

Int. J. Pept. Protein Res. 41 , 411-414, (1993)

Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. ...

Convulsant properties of L-glutamic acid di-tert butyl ester.

Neurobehav. Toxicol. Teratol. 7 , 275-278, (1985)

Glutamic acid di-tert butyl ester (GTBE) was found to have a pronounced convulsant effect in mice and rats, producing recurrent clonic convulsions combined with postural and respiratory disturbances i...