H-Glu(OtBu)-OtBu.HCl

Modify Date: 2024-01-02 18:30:48

H-Glu(OtBu)-OtBu.HCl structure	Common Name	H-Glu(OtBu)-OtBu.HCl
	CAS Number	32677-01-3	Molecular Weight	295.803
	Density	1.02g/cm3	Boiling Point	311.1ºC at 760 mmHg
	Molecular Formula	C₁₃H₂₆ClNO₄	Melting Point	60 to 75ºC
	MSDS	USA	Flash Point	78.1ºC

Use of H-Glu(OtBu)-OtBu.HCl

H-Glu(OtBu)-OtBu hydrochloride is a glutamate derivative that can be used for substance P antagonist synthesis[1].

Name	ditert-butyl (2S)-2-aminopentanedioate,hydrochloride
Synonym	More Synonyms

Description	H-Glu(OtBu)-OtBu hydrochloride is a glutamate derivative that can be used for substance P antagonist synthesis[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	Substance P[1]
References	[1]. Manolopoulou A, et al. Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids. Int J Pept Protein Res. 1993 Apr;41(4):411-4.

Density	1.02g/cm3
Boiling Point	311.1ºC at 760 mmHg
Melting Point	60 to 75ºC
Molecular Formula	C₁₃H₂₆ClNO₄
Molecular Weight	295.803
Flash Point	78.1ºC
Exact Mass	295.155029
PSA	78.62000
LogP	3.27960
Storage condition	−20°C

H-Glu(OtBu)-OtBu.HCl MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0880000

CHEMICAL NAME :: L-Glutamic acid, bis(1,1-dimethylethyl)ester, hydrochloride

CAS REGISTRY NUMBER :: 32677-01-3

LAST UPDATED :: 198703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H25-N-O4.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 7,275,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 7,275,1985

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MA0880000

DL-Glutamic acid

CAS#:617-65-2

Isobutylene

CAS#:115-11-7

~84%

H-Glu(OtBu)-OtBu.HCl

CAS#:32677-01-3

Literature: US2004/87813 A1, ;

Bis(2-methyl-2-...

CAS#:16881-41-7

H-Glu(OtBu)-OtBu.HCl

CAS#:32677-01-3

Literature: Recueil des Travaux Chimiques des Pays Bas, , vol. 102, # 11 p. 469 - 474

tert-Butyl acetate

CAS#:540-88-5

L-Glutamic acid...

CAS#:138-15-8

~40%

H-Glu(OtBu)-OtBu.HCl

CAS#:32677-01-3

Literature: Journal of Medicinal Chemistry, , vol. 37, # 20 p. 3294 - 3302

Precursor 5
CAS#:617-65-2 DL-Glutamic acid CAS#:115-11-7 Isobutylene CAS#:16881-41-7 Bis(2-methyl-2-... CAS#:540-88-5 tert-Butyl acetate
CAS#:138-15-8 L-Glutamic acid...
DownStream 8
CAS#:56-86-0 L-glutamic acid CAS#:2419-56-9 H-Glu(OtBu)-OH CAS#:45120-30-7 H-Glu-OtBu CAS#:4816-80-2 N-[(4-Methylphe...
CAS#:122665-73-0 cmda CAS#:3086-06-4 4-N-bis(2-chlor... CAS#:16881-41-7 Bis(2-methyl-2-... CAS#:86669-33-2 ditert-butyl 2-...

Synthesis and biological activity of analogues of the C-terminal hexapeptide of substance P with modifications at glutaminyl and methioninyl residues. Structure-activity studies.

Int. J. Pept. Protein Res. 40 , 395-400, (1992)

Analogues of [Orn6]-SP6-11 have been synthesized in which the methionyl residue is replaced by glutamine gamma-carboxamide substituted derivatives. These analogues where tested in three in vitro prepa...

Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.

Int. J. Pept. Protein Res. 41 , 411-414, (1993)

Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. ...

Convulsant properties of L-glutamic acid di-tert butyl ester.

Neurobehav. Toxicol. Teratol. 7 , 275-278, (1985)

Glutamic acid di-tert butyl ester (GTBE) was found to have a pronounced convulsant effect in mice and rats, producing recurrent clonic convulsions combined with postural and respiratory disturbances i...

H-Glu(OtBu)-OtBu·HCl

H-Glu(OtBu)-OtBuï¿½ï¿½HCl

L-glutamic acid di-t-butyl ester hydrochloride

MFCD00058003

Di-tert-butyl L-glutamate hydrochloride (1:1)

L-Glutamic acid, bis(1,1-dimethylethyl) ester, hydrochloride (1:1)

H-Glu(OtBu)-OtBu,HCl

H-L-Glu(OtBu)-OtBu*HCl

L-Glutamic acid di-tert

L-Glutamic Acid di-Tert-Butyl Ester Hydrochloride

Bis(2-methyl-2-propanyl) L-glutamate hydrochloride (1:1)

(S)-Di-tert-butyl 2-aminopentanedioate hydrochloride

H-Glu(OtBu)-OtBu.HCl

L-Glutamic acid di-tert-butylester hydrochloride

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: H-Glu(OtBu)-OtBu.HCl
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Purity: 98.0%
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GL Biochem (Shanghai) Ltd.
China
Product Name: H-Glu(OtBu)-OtBu.HCl
Price: $Inquiry/1kg
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: H-Glu(OtBu)-OtBu.HCl
Price: ￥508.0/5g ￥168.0/1g
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
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Nanjing Peptide Biotech Ltd
China
Product Name: H-Glu(OtBu)-OtBu.HCl
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Delivery: 7 Day
Contact: jom
Email: chenglong.fan@njpeptide.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-Glutamic acid di-tert-butyl ester hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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H-Glu(OtBu)-OtBu.HCl

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