2-Aminobenzenesulfonamide

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Names

[ CAS No. ]:
3306-62-5

[ Name ]:
2-Aminobenzenesulfonamide

[Synonym ]:
2-Aminobenzenesulfonamide
orthanilamide
aminobenzenesulfonamide
2-Sulphamoylaniline
EINECS 221-988-1
MFCD08443599
sulfamoylaniline
o-sulfanilamide
2-amino-benzenesulfonamid
Benzenesulfonamide, 2-amino-
o-amino-benzenesulfonamid
2-Aminobenzenesulfonamde
2-Amino-Benzensulfonamide
o-aminobenzenesulfonamide
2-Aminobenzenesulfamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
392.7±44.0 °C at 760 mmHg

[ Melting Point ]:
155-157 °C(lit.)

[ Molecular Formula ]:
C6H8N2O2S

[ Molecular Weight ]:
172.205

[ Flash Point ]:
191.3±28.4 °C

[ Exact Mass ]:
172.030655

[ PSA ]:
94.56000

[ LogP ]:
0.22

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.628

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA9449000
CHEMICAL NAME :
Benzenesulfonamide, o-amino-
CAS REGISTRY NUMBER :
3306-62-5
BEILSTEIN REFERENCE NO. :
0512329
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H8-N2-O2-S
MOLECULAR WEIGHT :
172.22
WISWESSER LINE NOTATION :
ZSWR BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 10,319,1937 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84518 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 168 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S36/37/39-S26-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DA9449000

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Nitrobenzenesulfonamide
  • 2-(β-hydroxyethylamino)-5-nitrobenzenesulphonamide
  • 1,1-dioxo-4H-1λ6,2,4-benzothiadiazin-3-one
  • o-Nitrophenylsulfonyl chloride
  • 3-Nitrophenylsulfonyl chloride
  • N-chlorosulfonyl-N'-phenyl-urea
  • 2-Chlorobezenesulfonamide

DownStream

  • 2-AMINO-5-BROMOBENZENESULPHONAMIDE
  • Benzenesulfonamide, 2-(methylamino)- (9CI)
  • 2,5-Diaminobenzenesulfonamide
  • diazoxide
  • 2-Aminobenzenesulfonic acid
  • 2H-1,2,4-Benzothiadiazine 1,1-dioxide
  • 2H-1,2,4-Benzothiadiazine, 3,4-dihydro-3-methyl-, 1,1-dioxide
  • 7-BROMO-2H-1,2,4-BENZOTHIADIAZIN-3(4H)-ONE 1,1-DIOXIDE
  • 9-methyl-10,10-dioxo-10$l^{6}-thia-7,9-diazabicyclo[4.4.0]deca-1,3,5-trien-8-one
  • 1,1-dioxo-4H-1λ6,2,4-benzothiadiazin-3-one

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety.

Bioorg. Med. Chem. 16(6) , 2955-67, (2008)

Inhibition of the hepatitis C virus (HCV) NS3 protease has emerged as an attractive approach to defeat the global hepatitis C epidemic. In this work, we present the synthesis and biochemical evaluatio...

Nitrogen-15 nuclear magnetic resonance study of benzenesulfonamide and cyanate binding to carbonic anhydrase.

Biochemistry 22 , 2658, (1983)

Heterocycles with a benzothiadiazepine moiety. 5. Derivatives of pyrrolo[2,1-d][1,2,5]benzothiadiazepine, a novel tricyclic ring.

Il Farmaco 52(6-7) , 375-8, (1997)

The synthesis of pyrrolo[2,1-d][1,2,5]benzothiadiazepin-7(6H)-one 5,5-dioxide has been achieved by reaction between 2-(1H-pyrrol-1-yl)benzenesulfonamide and triphosgene. N-Ethylation of the tricyclic ...


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Related Compounds

  • 2-AMINOBENZENESULFONAMIDE
  • 5-iodo-2-aminobenzenesulfonamide
  • 4-bromo-2-aminobenzenesulfonamide
  • 5-nitro-2-aminobenzenesulfonamide
  • 5-cyano-2-aminobenzenesulfonamide
  • 3-ethyl-2-aminobenzenesulfonamide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-[6,7-Dihydro-1-(methylthio)-5H-cyclopenta[c]pyridin-3-yl]-1H-indole
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4-(3-amino-4-methoxybenzyl)-2H-phthalazin-1-one
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine