2-Aminobenzenesulfonamide

Modify Date: 2024-01-07 12:54:14

2-Aminobenzenesulfonamide Structure
2-Aminobenzenesulfonamide structure
Common Name 2-Aminobenzenesulfonamide
CAS Number 3306-62-5 Molecular Weight 172.205
Density 1.4±0.1 g/cm3 Boiling Point 392.7±44.0 °C at 760 mmHg
Molecular Formula C6H8N2O2S Melting Point 155-157 °C(lit.)
MSDS Chinese USA Flash Point 191.3±28.4 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2-Aminobenzenesulfonamide


2-Aminobenzenesulfonamide is a carbonic anhydrase IX inhibitor.

 Names

Name 2-Aminobenzenesulfonamide
Synonym More Synonyms

 2-Aminobenzenesulfonamide Biological Activity

Description 2-Aminobenzenesulfonamide is a carbonic anhydrase IX inhibitor.
Related Catalog
Target

carbonic anhydrase IX[1]

References

[1]. Vullo D, et al. Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1005-9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 392.7±44.0 °C at 760 mmHg
Melting Point 155-157 °C(lit.)
Molecular Formula C6H8N2O2S
Molecular Weight 172.205
Flash Point 191.3±28.4 °C
Exact Mass 172.030655
PSA 94.56000
LogP 0.22
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.628

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA9449000
CHEMICAL NAME :
Benzenesulfonamide, o-amino-
CAS REGISTRY NUMBER :
3306-62-5
BEILSTEIN REFERENCE NO. :
0512329
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H8-N2-O2-S
MOLECULAR WEIGHT :
172.22
WISWESSER LINE NOTATION :
ZSWR BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 10,319,1937 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84518 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 168 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S36/37/39-S26-S22
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DA9449000
HS Code 2935009090

 Synthetic Route

~90%

2-Aminobenzenesulfonamide Structure

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CAS#:3306-62-5

Literature: Ismail, Mohamed A.H.; Abou El Ella, Dalal A.; Abouzid, Khaled A.M.; Mahmoud, Amr H. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5647 - 5647

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CAS#:3306-62-5

Literature: US4806640 A1, ;

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CAS#:3306-62-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 14 p. 3833 - 3838

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2-Aminobenzenesulfonamide Structure

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CAS#:3306-62-5

Literature: US4976773 A1, ;

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2-Aminobenzenesulfonamide Structure

2-Aminobenzenes...

CAS#:3306-62-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 14 p. 3833 - 3838

~%

2-Aminobenzenesulfonamide Structure

2-Aminobenzenes...

CAS#:3306-62-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 14 p. 3833 - 3838

~%

2-Aminobenzenesulfonamide Structure

2-Aminobenzenes...

CAS#:3306-62-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 14 p. 3887 - 3890

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CAS#:3306-62-5

Literature: Bioorganic and Medicinal Chemistry, , vol. 20, # 7 p. 2455 - 2478

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2-Aminobenzenesulfonamide Structure

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CAS#:3306-62-5

Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2> 95, p. 393

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Articles3

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Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety.

Bioorg. Med. Chem. 16(6) , 2955-67, (2008)

Inhibition of the hepatitis C virus (HCV) NS3 protease has emerged as an attractive approach to defeat the global hepatitis C epidemic. In this work, we present the synthesis and biochemical evaluatio...

Nitrogen-15 nuclear magnetic resonance study of benzenesulfonamide and cyanate binding to carbonic anhydrase.

Biochemistry 22 , 2658, (1983)

Heterocycles with a benzothiadiazepine moiety. 5. Derivatives of pyrrolo[2,1-d][1,2,5]benzothiadiazepine, a novel tricyclic ring.

Il Farmaco 52(6-7) , 375-8, (1997)

The synthesis of pyrrolo[2,1-d][1,2,5]benzothiadiazepin-7(6H)-one 5,5-dioxide has been achieved by reaction between 2-(1H-pyrrol-1-yl)benzenesulfonamide and triphosgene. N-Ethylation of the tricyclic ...

 Synonyms

2-Aminobenzenesulfonamide
orthanilamide
aminobenzenesulfonamide
2-Sulphamoylaniline
EINECS 221-988-1
MFCD08443599
sulfamoylaniline
o-sulfanilamide
2-amino-benzenesulfonamid
Benzenesulfonamide, 2-amino-
o-amino-benzenesulfonamid
2-Aminobenzenesulfonamde
2-Amino-Benzensulfonamide
o-aminobenzenesulfonamide
2-Aminobenzenesulfamide
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