3-Methylvaline

Suppliers

Names

[ Name ]:
3-Methylvaline

[Synonym ]:
L-2-(tert-butyl)glycine
tert-leucine
L-Tert-Leucine
L-tert-leucin
(S)-2-Amino-3,3-dimethylbutyric acid
LEUCINE,L
2-tert-butyl-glycine
DL-Tert-Leucine
3-Methylvaline
(S)-2-Amino-4-methylpentanoic acid
T-BUTYL GLYCINE
DL-tert-Butylglycine
L-2-amino-3,3-dimethylbutanoic acid
(2S)-2-amino-3,3-dimethylbutanoic acid
3-Methyl-L-valine
L-Valine, 3-methyl-
L-2-tert-Butylglycine
Valine, 3-methyl-
(S)-2-Amino-3,3-dimethylbutanoic acid
3-Methyl valine
t-Butylglycine
h-dl-tle-oh
L-α-tert-Butylglycine
dl-t-butylglycine
L-tert
H-L-LEU-OH
QVYZX1&1&1 &&L or S Form
2-Amino-3,3-dimethylbutanoic acid
2-amino-3,3-dimethyl-butyric acid
tert-butylglycine
MFCD00065933
H-Tle-OH

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
217.7±23.0 °C at 760 mmHg

[ Melting Point ]:
299-301ºC

[ Molecular Formula ]:
C₆H₁₃NO₂

[ Molecular Weight ]:
131.173

[ Flash Point ]:
85.5±22.6 °C

[ Exact Mass ]:
131.094635

[ PSA ]:
63.32000

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.464

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
H2O: 0.1 g/mL, clear, colorless | soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

D-tert-Leucine
Trimethylpyruvic acid
2-hydroxyimino-3,3-dimethylbutanoic acid
3,3-dimethyl-2-oxo-butanoic acid phenyhydrazone
Pinacolone
Pivaldehyde
2-azido-1-cyano-1-methoxy-3,3-dimethylbutyl nitrate

DownStream

D-tert-Leucine
Trimethylpyruvic acid
L-tert-Leucine
L-tert-leucine hydrochloride
5-tert-butylimidazolidine-2,4-dione
4-tert-butyl-2-phenyl-4H-1,3-oxazol-5-one
3,3-dimethyl-2-(phenylmethoxycarbonylamino)butanoic acid
(+)-N-(O-CHLOROBENZYL)-ALPHA-METHYLPHENETHYLAMINEHYDROCHLORIDE
(-)-n-formyl-l-tert-leucine
methyl 2-amino-3,3-dimethylbutanoate

Articles

Highly selective asymmetric acetate aldol reactions of an N-acetyl thiazolidinethione reagent.

Org. Lett. 6 , 23-25, (2004)

[reaction: see text] A highly diastereoselective acetate aldol reaction that uses a tert-leucine-derived thiazolidinethione auxiliary and dichlorophenylborane has been developed. The reaction proceeds...

Scaleable catalytic asymmetric Strecker syntheses of unnatural alpha-amino acids.

Nature 461(7266) , 968-70, (2009)

Alpha-amino acids are the building blocks of proteins and are widely used as components of medicinally active molecules and chiral catalysts. Efficient chemo-enzymatic methods for the synthesis of ena...

An efficient and selective enzymatic oxidation system for the synthesis of enantiomerically pure D-tert-leucine.

Org. Lett. 5(20) , 3649-50, (2003)

[reaction: see text] d-tert-Leucine was prepared with an enantiomeric excess of >99% by an enzyme-catalyzed oxidative resolution of the racemic mixture of dl-tert-leucine with use of leucine dehydroge...