3-Bromo-4-methylpyridine

Names

[ Name ]:
3-Bromo-4-methylpyridine

[Synonym ]:
4-Methyl-3-bromopyridine
3-Bromo-4-methylpyridine
3-Bromo-4-methyl-pyridine
3-Bromo-4-picoline
Pyridine, 3-bromo-4-methyl-
3-brom-4-methylpyridin
bromo-3 methyl-4 pyridine
MFCD00082592

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
198.8±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₆BrN

[ Molecular Weight ]:
172.023

[ Flash Point ]:
74.1±21.8 °C

[ Exact Mass ]:
170.968353

[ PSA ]:
12.89000

[ LogP ]:
2.21

[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.553

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S2636

[ RIDADR ]:
Cool, dry,tightly closed

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Picoline
1(4H)-Pyridinecarboxylic acid, 3-bromo-4-methyl-, phenyl ester
3-Bromopyridine
methyl iodide
Lithium diisopropylamide

DownStream

(4-Methylpyridin-3-yl)methanol
Ethyl 2-(3-bromopyridin-4-yl)acetate
4-Methylnicotinic acid
Methyl 4-methylnicotinate
4-Methylnicotinaldehyde
TERT-BUTYL 2-CHLOROPYRIDIN-4-YLCARBAMATE
3-BROMO-4-(3-HYDROXYPROPYL)PYRIDINE
4-Picoline
4-Methylnicotinonitrile
3-Ethynyl-4-methylpyridine

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Tricyclic pyridones as functionally selective human GABAA alpha 2/3 receptor-ion channel ligands.

Bioorg. Med. Chem. Lett. 14(7) , 1679-82, (2004)

A series of tricyclic pyridones has been evaluated as benzodiazepine site ligands with functional selectivity for the alpha(3) over the alpha(1) containing subtype of the human GABA(A) receptor ion ch...

Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters.

Bioorg. Med. Chem. Lett. 12(20) , 3009-13, (2002)

A detailed SAR study directed toward the optimization of pharmacokinetic parameters for analogues of L-791,943 is reported. The introduction of a soft metabolic site on this structure permitted the id...

Total synthesis of ascididemin via anionic cascade ring closure.

Chem. Commun. (Camb.) 48(72) , 9092-4, (2012)

A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2...

3-Bromo-4-methylpyridine
3-bromo-4-methylpyridine N-oxide
2-HYDROXY-3-BROMO-4-METHYLPYRIDINE
3-bromo-4-methylpyridine-2,5-diamine
2-(Benzyloxy)-3-bromo-4-methylpyridine
3-bromo-4-methylpyridine-2-carbonitrile
tert-butylN-(1,2,3-thiadiazol-4-yl)carbamate
(2S)-3-(2-Chloro-4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
4-[(dimethylamino)methyl]-N-methylbenzene-1-sulfonamide
2-Methoxy-2-methyl-3-phenylmethoxypropanoic acid
(2S)-3-cyclooctyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
1-methyl-5-[3-(propan-2-yl)phenyl]-1H-pyrazol-4-amine
Methyl 2-((tert-butoxycarbonyl)amino)-3-(2,6-difluorophenyl)propanoate
Methyl 2-((tert-butoxycarbonyl)amino)-3-(thiophen-3-yl)propanoate
4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazole-5-carboxylic acid
tert-butyl (3aS,8bR)-4-amino-5-fluoro-3,3a,4,8b-tetrahydro-1H-indeno[1,2-c]pyrrole-2-carboxylate

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