5'-DEOXYTHYMIDINE

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Names

[ CAS No. ]:
3458-14-8

[ Name ]:
5'-DEOXYTHYMIDINE

[Synonym ]:
MFCD00057398
1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione
5'-Deoxythymidine

Chemical & Physical Properties

[ Density]:
1.344g/cm3

[ Melting Point ]:
192-193ºC(lit.)

[ Molecular Formula ]:
C10H13IN2O4

[ Molecular Weight ]:
352.13

[ Exact Mass ]:
226.09500

[ PSA ]:
84.32000

[ Index of Refraction ]:
1.559

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-[(2R,4S,5S)-5-(chloromethyl)-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
  • 5'-O-(phenoxythiocarbonyl)thymidine
  • Thymidine
  • Thymidine,5'-deoxy-5'-iodo-
  • 3'-O-Ac-dT

DownStream

  • Uridine,2',5'-dideoxy-5-fluoro-
  • Thymine

Articles

Thymidine inhibits the growth-arrest-specific degradation of thymidine kinase protein in transfected L fibroblasts.

J. Mol. Biol. 265(2) , 153-60, (1997)

The expression of murine thymidine kinase (TK) is strictly dependent on the growth state of the cell. Expressing epitope-tagged TK in LTK cells, we have previously shown that low TK enzyme levels in G...

Membrane permeation characteristics of 5'-modified thymidine analogs.

Mol. Pharmacol. 41(5) , 950-6, (1992)

The membrane permeation characteristics of 5'-deoxythymidine (5'-ddThd) and 5'-azido-5'-deoxythymidine (5'-N3-5'-ddThd) were investigated in human erythrocytes, with an inhibitor-stop assay, at 20 deg...

Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives.

Arzneimittelforschung 53(4) , 266-71, (2003)

In this study, the synthesis of some benzoxazoles and their analogues were described and their antiviral activities were studied together with the previously synthesized 2,5,6-trisubstituted benzoxazo...


More Articles

Related Compounds

  • 5'-iodo-5'-deoxythymidine
  • 5'-iodo-5'-deoxythymidine
  • 5'-bromo-5'-deoxythymidine
  • 5'-amino-5'-deoxythymidine
  • 5'-Azido-5'-deoxythymidine
  • 5'-isocyano-5'-deoxythymidine