L-Thioproline
Suppliers
Names
[ CAS No. ]:
34592-47-7
[ Name ]:
L-Thioproline
[Synonym ]:
H-THZ-OH
L-Thiazolidine-4-car
(R)-4-Thiazolidinecarboxylic acid
EINECS 252-106-3
L-THC
THIAPROLINE
(4R)-4-Thiazolidinecarboxylic acid
(4R)-thiazolidine-4-carboxylic acid
1,3-Thiazolidine-2-carboxylic acid
Thiazolidinecarboxylic acid (VAN)
THIAZOLIDINECARBOXYLIC ACID
2-Thiazolidinecarboxylic acid
DL-Thiazolidinecarboxylic acid
L(-)-Thiazolidine-4-carboxylicacid
L(-)-Thiazolidine-4-Carboxylic Acid
L-Thiazolidine-4-carboxylic acid
H-L-THZ-OH
MFCD00005212
(4R)-1,3-Thiazolidine-4-carboxylic acid
L-4-Thiazolidinecarboxylic acid
L-Thioproline
thiazolidinecarboxylicacid
(R)-(-)-4-Thiazolidinecarboxylic acid
L- thiazolidine-4-carboxylic acid
THIOPROLINE
H-THIOPRO-OH
L-THIAPROLINE
(R)-Thiazolidine-4-carboxylic acid
(R)-(-)-Thiazolidine-4-carboxylic Acid
L-thiazoline-4-carboxylic acid
4-Thiazolidinecarboxylic acid, (4R)-
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
350.3±37.0 °C at 760 mmHg
[ Melting Point ]:
190-200 °C (dec.)(lit.)
[ Molecular Formula ]:
C4H7NO2S
[ Molecular Weight ]:
133.169
[ Flash Point ]:
165.7±26.5 °C
[ Exact Mass ]:
133.019745
[ PSA ]:
74.63000
[ LogP ]:
-0.39
[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C
[ Index of Refraction ]:
1.566
[ Water Solubility ]:
28.5 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XJ5425500
- CHEMICAL NAME :
- 4-Thiazolidinecarboxylic acid, L-
- CAS REGISTRY NUMBER :
- 34592-47-7
- LAST UPDATED :
- 199610
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C4-H7-N-O2-S
- MOLECULAR WEIGHT :
- 133.18
- WISWESSER LINE NOTATION :
- T5M CSTJ EVQ -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2547728
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 178 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00644
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H312-H315-H319-H332-H335
[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S26-S36/37/39-S36
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
XJ5425500
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
29341000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Bioorg. Med. Chem. 19 , 6409-18, (2011)
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...
Biochimie 94(2) , 533-40, (2012)
Herein we describe the design, synthesis and biological activities of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors. The target compounds 2a-2j were d...
Mol. Divers. 10(2) , 223-31, (2006)
By using internal combinatorial library we were able to identify (4R)-thiazolidines carboxylic acid and its 2-substituted analogs as active inhibitors of urease. Molecular modeling and virtual screeni...