D-methionine

Suppliers

Names

[ CAS No. ]:
348-67-4

[ Name ]:
D-methionine

[Synonym ]:
R-Methionine
(R)-2-amino-4-(methylthio)butanoic acid
Methionine, D-
D-Methionin
d-Met
(2R)-2-amino-4-(methylsulfanyl)butanoic acid
(R)-methionine
D-Methionine
(R)-2-Amino-4-(methylmercapto)butyric acid (D-2-Amino-4-(methylthio)butanoic acid
EINECS 206-483-6
(2R)-2-amino-4-methylsulfanylbutanoic acid
H-D-Met-OH
MFCD00002622
H-D-Met-OEt.HCl
MRX-1024

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
306.9±37.0 °C at 760 mmHg

[ Melting Point ]:
273-275ºC

[ Molecular Formula ]:
C₅H₁₁NO₂S

[ Molecular Weight ]:
149.211

[ Flash Point ]:
139.4±26.5 °C

[ Exact Mass ]:
149.051056

[ PSA ]:
88.62000

[ LogP ]:
0.37

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.531

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PD0455000

CHEMICAL NAME :: Methionine, D-

CAS REGISTRY NUMBER :: 348-67-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H11-N-O2-S

MOLECULAR WEIGHT :: 149.23

WISWESSER LINE NOTATION :: QVYZ2S1 -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5223 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956 *** REVIEWS *** TOXICOLOGY REVIEW JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 22,2,1974

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R33

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
PD0455000

[ HS Code ]:
2930400000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DL-Methionine
N-Acetyl-DL-methionine
2-amino-4-(methylthio)butanamide hydrochloride
formyl-D-methionine
4-(methyl thio)-2-oxobutyric acid
Z-Met-OH
ethyl DL-methionate
2-(benzylsulfonylamino)-4-methylsulfanyl-butanoic acid
DL-Homocysteine
For-DL-Met-OH

DownStream

dl-methioninol
Methyl methioninate
D(-)-Glutamic acid
4-(methyl thio)-2-oxobutyric acid
H-D-Met-OMe.HCl
L-Homoserine
N-Boc-D-methionine
Dimethylselenide
N-Acetyl-DL-methionine
H-D-Abu-OH

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.

PLoS ONE 4(5) , e5492, (2009)

The transcription factor Nrf2 is the master regulator of a cellular defense mechanism against environmental insults. The Nrf2-mediated antioxidant response is accomplished by the transcription of a ba...

Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition.

J. Neural Transm. Gen. Sect. 121(7) , 683-93, (2014)

Antioxidants are well known for their neuroprotective properties against reactive oxygen species in cortical neurons and auditory cells. We recently identified L-carnitine and D-methionine to be among...

D-methionine (D-met) significantly rescues noise-induced hearing loss: timing studies.

Hear. Res. 282 , 138-144, (2011)

We have previously reported rescue from noise-induced auditory brainstem response (ABR) threshold shifts with d-methionine (d-met) administration 1 h after noise exposure. The present study investigat...