D-methionine

Modify Date: 2026-06-30 20:08:44

D-methionine structure	Common Name	D-methionine
	CAS Number	348-67-4	Molecular Weight	149.211
	Density	1.2±0.1 g/cm3	Boiling Point	306.9±37.0 °C at 760 mmHg
	Molecular Formula	C₅H₁₁NO₂S	Melting Point	273-275ºC
	MSDS	Chinese USA	Flash Point	139.4±26.5 °C

Use of D-methionine

Methionine (MRX-1024) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	D-methionine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Methionine (MRX-1024) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Cancer Research Areas >> Neurological Disease
Target	GABAA receptor[1]
In Vitro	The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. In plasma, an early CP hydrolysis product reacts with Methionine to form a 1:1 complex that is followed by the formation of a 2:1 compound at a later time point. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities[2].
In Vivo	When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01) while not significantly different from controls or from animals treated only with D-methionine (P>0.05). When Methionine is administered alone the average cell density is 0.95±0.099 (SEM) and not significantly different from controls (P>0.05)[3].
Cell Assay	Plasma (2.0 mL) is spiked with 81 mL of the CP stock solution, incubated at 37°C for 30 min and then 20 mL of theMethionine (D-methionine) stock solution (40.7 mg/mL) is added. The obtained mixture is analyzed after 10 min and 50 min of incubation at 37°C[2].
Animal Admin	Three sham controls receive 0.9% saline instead of cisplatin. Three rats receive only cisplatin. Another three rats receive Methionine (D-methionine) 30 minutes prior to treatment with cisplatin. Injection of Methionine prior to cisplatin treatment ensures that it is already taken up before cisplatin is applied. Finally, three rats are treated only with Methionine. All 12 rats are sacrificed at day 7 post-treatment. For prescreening, two further rats are treated with cisplatin alone and sacrificed 2 or 21 days later. All rats are hydrated with 0.9% saline[3].
References	[1]. Wu C, et al. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. J Neural Transm (Vienna). 2014 Jul;121(7):683-93. [2]. Sooriyaarachchi M, et al. Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitrostudies using human plasma. Metallomics. 2014 Mar;6(3):532-41. [3]. Hinduja S, et al. D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotox Res. 2015 Apr;27(3):199-204.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	306.9±37.0 °C at 760 mmHg
Melting Point	273-275ºC
Molecular Formula	C₅H₁₁NO₂S
Molecular Weight	149.211
Flash Point	139.4±26.5 °C
Exact Mass	149.051056
PSA	88.62000
LogP	0.37
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.531
InChIKey	FFEARJCKVFRZRR-SCSAIBSYSA-N
SMILES	CSCCC(N)C(=O)O
Storage condition	2~8°C

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

D-methionine MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PD0455000

CHEMICAL NAME :: Methionine, D-

CAS REGISTRY NUMBER :: 348-67-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H11-N-O2-S

MOLECULAR WEIGHT :: 149.23

WISWESSER LINE NOTATION :: QVYZ2S1 -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5223 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956 *** REVIEWS *** TOXICOLOGY REVIEW JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 22,2,1974

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R33
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	PD0455000
HS Code	2930400000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:59-51-8 DL-Methionine CAS#:1509-92-8 N-Acetyl-DL-met... CAS#:52811-68-4 2-amino-4-(meth... CAS#:44978-50-9 formyl-D-methionine
CAS#:583-92-6 4-(methyl thio)... CAS#:1152-62-1 Z-Met-OH CAS#:452-95-9 ethyl DL-methionate CAS#:7469-26-3 2-(benzylsulfon...
CAS#:454-29-5 DL-Homocysteine CAS#:4309-82-4 For-DL-Met-OH
DownStream 10
CAS#:502-83-0 dl-methioninol CAS#:21691-49-6 Methyl methioninate CAS#:6893-26-1 D(-)-Glutamic acid CAS#:583-92-6 4-(methyl thio)...
CAS#:69630-60-0 H-D-Met-OMe.HCl CAS#:6027-21-0 L-Homoserine CAS#:5241-66-7 N-Boc-D-methionine CAS#:593-79-3 Dimethylselenide
CAS#:1509-92-8 N-Acetyl-DL-met... CAS#:2623-91-8 H-D-Abu-OH

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.

PLoS ONE 4(5) , e5492, (2009)

The transcription factor Nrf2 is the master regulator of a cellular defense mechanism against environmental insults. The Nrf2-mediated antioxidant response is accomplished by the transcription of a ba...

Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition.

J. Neural Transm. Gen. Sect. 121(7) , 683-93, (2014)

Antioxidants are well known for their neuroprotective properties against reactive oxygen species in cortical neurons and auditory cells. We recently identified L-carnitine and D-methionine to be among...

D-methionine (D-met) significantly rescues noise-induced hearing loss: timing studies.

Hear. Res. 282 , 138-144, (2011)

We have previously reported rescue from noise-induced auditory brainstem response (ABR) threshold shifts with d-methionine (d-met) administration 1 h after noise exposure. The present study investigat...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist

Name: Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E...
Source: NCGC
External Id: epac1-activator-v

Name: Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inh...
Source: ChEMBL
Target: Large neutral amino acids transporter small subunit 1
External Id: CHEMBL4234829

Name: Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3...
Source: NCGC
External Id: epac1-inhibitor-v

Name: Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (E...
Source: NCGC
External Id: epac2-activator-v2

Name: Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4...
Source: NCGC
External Id: epac2-inhibitor-v2

Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082

Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100

Name: qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar...
Source: NCGC
Target: 67.9K protein [Vaccinia virus]
External Id: Vaccinia-p2mCherry

Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101

Total 19, Current Page 1 of 2

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

R-Methionine

(R)-2-amino-4-(methylthio)butanoic acid

D-Methionin

d-Met

(2R)-2-amino-4-(methylsulfanyl)butanoic acid

(R)-methionine

D-Methionine

(R)-2-Amino-4-(methylmercapto)butyric acid (D-2-Amino-4-(methylthio)butanoic acid

EINECS 206-483-6

(2R)-2-amino-4-methylsulfanylbutanoic acid

H-D-Met-OH

MFCD00002622

H-D-Met-OEt.HCl

MRX-1024

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of D-methionine?

A: SMILES notation of D-methionine is CSCCC(N)C(=O)O.

Q: What is the LogP of D-methionine?

A: LogP of D-methionine is 0.37.

Q: What is the polar surface area (PSA) of D-methionine?

A: Polar surface area (PSA) of D-methionine is 88.62000.

Q: What is the CAS number of D-methionine?

A: CAS number of D-methionine is 348-67-4.

Q: What is the molecular formula of D-methionine?

A: Molecular formula of D-methionine is C5H11NO2S.

Q: What are the storage conditions for D-methionine?

A: Storage conditions for D-methionine: 2~8°C.

Q: What is the safety information for D-methionine?

A: Safety information for D-methionine: S22-S24/25.

Q: What is the melting point of D-methionine?

A: Melting point of D-methionine is 273-275ºC.

Q: What is the English name of D-methionine?

A: The English name of D-methionine is D-methionine.

Q: What is the boiling point of D-methionine?

A: Boiling point of D-methionine is 306.9±37.0 °C at 760 mmHg.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: D-methionine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: D-Methionine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM CAS NO.348-67-4 D-Methionine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: D-methionine
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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D-methionine suppliers

Price: $66/10mM*1mLinDMSO

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D-methionine

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.