LHRH (free acid) trifluoroacetate salt

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Names

[ Name ]:
LHRH (free acid) trifluoroacetate salt

[Synonym ]:
PYR-HWSYGLRPG
GONADOTROPIN-RELEASING HORMONE
PYR-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY
LUTEINIZING HORMONE-RELEASING HORMONE
mammalian GnRH I
luteinizing hormone releasing hormone free acid
pEHWSYGLRPG
<Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH >
GLP-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH

Chemical & Physical Properties

[ Density]:
1.54 g/cm3

[ Molecular Formula ]:
C₅₅H₇₄N₁₆O₁₄

[ Molecular Weight ]:
1183.27

[ Exact Mass ]:
1182.56000

[ PSA ]:
466.34000

[ LogP ]:
1.00640

[ Index of Refraction ]:
1.709

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360

[ Precautionary Statements ]:
P201-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R60

[ Safety Phrases ]:
53-22-36/37/39-45

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Articles

Direct regulation of gonadotrophin-releasing hormone (GnRH) transcription by RF-amide-related peptide-3 and kisspeptin in a novel GnRH-secreting cell line, mHypoA-GnRH/GFP.

J. Neuroendocrinol. 26(12) , 888-97, (2014)

RF-amide-related peptide-3 [RFRP-3; also often referred to as the mammalian orthologue of the avian gonadotrophin-inhibitory hormone (GnIH)] and kisspeptin have emerged as potent modulators of neuroen...

Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation.

Mol. Cell. Endocrinol. 402 , 95-106, (2015)

Transmembrane helix seven residues of G protein-coupled receptors (GPCRs) couple agonist binding to a conserved receptor activation mechanism. Amino-terminal residues of the GnRH peptide determine ago...

Live birth rates after combined adjuvant therapy in IVF-ICSI cycles: a matched case-control study.

Reprod. Biomed. Online 30(4) , 340-8, (2015)

The effectiveness of combined co-treatment with aspirin, doxycycline, prednisolone, with or without oestradiol patches, was investigated on live birth (LBR) rates after fresh and frozen embryo transfe...

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