CHLOTAZOLE

Suppliers

Names

[ CAS No. ]:
35317-79-4

[ Name ]:
CHLOTAZOLE

[Synonym ]:
2,2,2-trichloro-1-thiazol-2-ylamino-ethanol
2,2,2-Trichlor-1-thiazol-2-ylamino-aethanol
Clotazol
Khlotazol
Chlotazole

Chemical & Physical Properties

[ Density]:
1.765g/cm3

[ Boiling Point ]:
301ºC at 760 mmHg

[ Molecular Formula ]:
C5H5Cl3N2OS

[ Molecular Weight ]:
247.53000

[ Flash Point ]:
135.8ºC

[ Exact Mass ]:
245.91900

[ PSA ]:
73.39000

[ LogP ]:
2.31660

[ Index of Refraction ]:
1.68

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM4950000
CHEMICAL NAME :
Ethanol, 2,2,2-trichloro-1-(2-thiazolylamino)-
CAS REGISTRY NUMBER :
35317-79-4
BEILSTEIN REFERENCE NO. :
0152089
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C5-H5-Cl3-N2-O-S
MOLECULAR WEIGHT :
247.53
WISWESSER LINE NOTATION :
T5N CSJ BMYQXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 17,519,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 46,213,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
708 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2400361
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 17,519,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 17,519,1983

Synthetic Route

Precursor & DownStream

Precursor

  • 2-Aminothiazole
  • Chloral

DownStream


Related Compounds

  • 6-Chloro-2-methyl-5-(trifluoromethoxy)pyridine-3-sulfonamide
  • 2-Cyano-6-(difluoromethyl)-5-fluoronicotinamide
  • (5-Methyl-1,3,4-oxadiazol-2-yl)-(6-phenylmethoxypyridin-2-yl)methanone
  • 4-[(1-Hydroxycyclobutyl)methyl]-1lambda-thiomorpholine-1,1-dione
  • 2-Pyrrolidinone, 4-(3,9-diazabicyclo[4.2.1]non-3-ylcarbonyl)-1-(4-methoxyphenyl)-
  • 1-[(Azepan-1-yl)methyl]cyclobutan-1-ol
  • 1-[(Pentylamino)methyl]cyclobutan-1-ol
  • 1-{[(2-Phenylethyl)amino]methyl}cyclobutan-1-ol
  • 1-({[(Oxolan-2-yl)methyl]amino}methyl)cyclobutan-1-ol
  • 1-{[(2-Hydroxyethyl)amino]methyl}cyclobutan-1-ol
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