N-(Hydroxymethyl)nicotinamide

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Names

[ CAS No. ]:
3569-99-1

[ Name ]:
N-(Hydroxymethyl)nicotinamide

[Synonym ]:
Pyridine-3-carboxylic Acid N-Methylolamide
3-Pyridinecarboxamide, N-(hydroxymethyl)-
Nicodine
Bilizorin
Cholamid
EINECS 222-668-4
Bilamid
3-Pyridinecarboxylic acid N-hydroxymethylamide
Nicoform
Cholamide
MFCD00010437
Nikomethamide
N-(hydroxymethyl)pyridine-3-carboxamide
Bilocid
N-(Hydroxymethyl)nicotinamide
Nicodin
hydroxymethylnicotinamide

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
427.7±25.0 °C at 760 mmHg

[ Melting Point ]:
152-154 °C(lit.)

[ Molecular Formula ]:
C7H8N2O2

[ Molecular Weight ]:
152.151

[ Flash Point ]:
212.5±23.2 °C

[ Exact Mass ]:
152.058578

[ PSA ]:
62.22000

[ LogP ]:
-0.80

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.569

[ Storage condition ]:
-20?C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QS4476500
CHEMICAL NAME :
Nicotinamide, N-(hydroxymethyl)-
CAS REGISTRY NUMBER :
3569-99-1
BEILSTEIN REFERENCE NO. :
0128633
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H8-N2-O2
MOLECULAR WEIGHT :
152.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 305,427,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 17,73,1960

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QS4476500

[ HS Code ]:
2933399090

Precursor & DownStream

Precursor

  • 3-Cyanopyridine
  • Formaldehyde
  • Nicotinamide

DownStream

  • Formaldehyde
  • Nicotinamide
  • 3-Cyanopyridine
  • N-[(2-hydroxynaphthalen-1-yl)methyl]pyridine-3-carboxamide

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[Study on the synthesis of N-hydroxymethyl-nicotinamide].

Yao Xue Xue Bao 27(8) , 629-31, (1992)

N-Hydroxymethyl-nicotinamide, an antimicrobic agent was prepared in good yield by treating nicotinamide with excess of formaldehyde in the presence of potassium carbonate. The condensation reaction wa...

Thin-layer chromatography-densitometric measurements for determination of N-(hydroxymethyl)nicotinamide in tablets and stability evaluation in solutions.

J. AOAC Int. 91(5) , 1186-90, (2008)

A thin-layer chromatography (TLC)-densitometric method was developed to determine N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid. Analysis was performed on sili...


More Articles

Related Compounds

  • N-ethyl-2-(hydroxymethyl)nicotinamide
  • N-benzyl-2-(hydroxymethyl)nicotinamide
  • N-(HYDROXYMETHYL)PIPERAZINE
  • N-hydroxymethyl-N-methylbenzamide
  • N-(hydroxymethyl)-2,2,3,3-tetramethylcyclopropane-1-carboxamide
  • N-hydroxymethyl-N-methylbenzylamine
  • N-[(4-methoxyphenyl)methyl]-3-(3-oxo-5-sulfanylidene-2,10a-dihydroimidazo[1,2-c]quinazolin-2-yl)propanamide
  • N-[2-(2-chlorophenyl)ethyl]-3-(3-oxo-5-sulfanylidene-2,6,6a,7,8,9,10,10a-octahydroimidazo[1,2-c]quinazolin-2-yl)propanamide
  • N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-5-(furan-2-yl)-1H-pyrazole-3-carboxamide
  • methyl 5-isopropyl-2-{[3-(5-methoxy-1H-indol-1-yl)propanoyl]amino}-1,3-thiazole-4-carboxylate
  • N-[3-(4-fluorobenzyl)-1H-1,2,4-triazol-5-yl]-3-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide
  • 4,7-Dimethyl-6-propan-2-yl-4a,9a-dihydropurino[7,8-a]imidazole-1,3-dione
  • 8-cyclopentyl-3-(3-hydroxypropyl)-1,7-dimethyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione
  • US10953012, Example 15
  • 4,7,8-Trimethyl-6-propan-2-yl-4a,9a-dihydropurino[7,8-a]imidazole-1,3-dione
  • N-(1-cyanocyclohexyl)-2-(4,4-dicyclopropyl-2,5-dioxoimidazolidin-1-yl)acetamide
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