rosamicin
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Names
[ CAS No. ]:
35834-26-5
[ Name ]:
rosamicin
[Synonym ]:
Rosaramicina [INN-Spanish]
Cirramycin A1,4'-deoxy
2-[(14E)-9-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]acetaldehyde
Antibiotic 67-694
Juvenimicin A3 Rosaramicin
ROSAMICIN
Juvenimicin A3
Rosaramicine [INN-French]
Antibiotic M 4365A2
Rosaramicin
Rosaramicinum [INN-Latin]
Chemical & Physical Properties
[ Density]:
1.17g/cm3
[ Boiling Point ]:
734.7ºC at 760mmHg
[ Melting Point ]:
119-122°
[ Molecular Formula ]:
C31H51NO9
[ Molecular Weight ]:
581.73800
[ Flash Point ]:
398.1ºC
[ Exact Mass ]:
581.35600
[ PSA ]:
135.13000
[ LogP ]:
2.67040
[ Index of Refraction ]:
1.532
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JG6800000
- CHEMICAL NAME :
- 4,17-Dioxabicyclo(14.1.0)heptadec-14-ene-10-acetaldeh yde, 3-ethyl-7-hydroxy-2,8,12,16- tetramethyl-5,13-dioxo-9-((3,4,6-trideoxy-3-(dimethyl amino)-beta-D-xylo-he xopyranosyl)oxy)-
- CAS REGISTRY NUMBER :
- 35834-26-5
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C31-H51-N-O9
- MOLECULAR WEIGHT :
- 581.83
- WISWESSER LINE NOTATION :
- T3-16- BO FOV OV PUTJ A1 D1 E2 IQ J1 L1VH N1 KO- BT6OTJ CQ DN1&1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,647,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 43,938,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 625 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,641,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 155 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,641,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4800 mg/kg/30D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,129,1983
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
20/21/22
[ Safety Phrases ]:
26-36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
JG6800000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Antibiot. 25 , 641, (1972)
Antimicrob. Agents Chemother. 57(3) , 1529-31, (2013)
The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by...
J. Bacteriol. 174(1) , 161-5, (1992)
Cell extracts of Streptomyces antibioticus, an oleandomycin producer, can inactivate oleandomycin in the presence of UDP-glucose. The inactivation can be detected through the loss of biological activi...