2',3'-O-Isopropylideneguanosine

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Names

[ CAS No. ]:
362-76-5

[ Name ]:
2',3'-O-Isopropylideneguanosine

[Synonym ]:
2',3'-O-Isopropylidene-D-guanosine
9-[(3aR,4R,6R,6aR)-4-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]-2-azanyl-3H-purin-6-one
9-(2,3-O-Isopropylidene-β-D-ribofuranosyl)guanine
2-amino-9-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-1H-purin-6(9H)-one
2',3'-O-Isopropylideneguanosine
2',3'-O-ISOPROPYLIDENE-GUANOSINE
9-[(3aR,4R,6R,6aR)-4-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]-2-amino-3H-purin-6-one
2',3'-O-(1-methylethylidene)-guanosine
2',3'-O-Isopropylide
EINECS 206-651-9
2-amino-9-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-1,9-dihydro-6H-purin-6-one
2',3'-ISOPROPYLIDENE-GUANOSINE
2′,3′-O-Isopropylideneguanosine
Guanosine, 2',3'-O-(1-methylethylidene)-
9-[(3aR,4R,6R,6aR)-2,2-dimethyl-4-methylol-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]-2-amino-3H-purin-6-one
2',3'-IPG
MFCD00057081

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
647ºC at 760mmHg

[ Melting Point ]:
296 °C

[ Molecular Formula ]:
C₁₃H₁₇N₅O₅

[ Molecular Weight ]:
323.305

[ Flash Point ]:
345.1ºC

[ Exact Mass ]:
323.122955

[ PSA ]:
137.51000

[ LogP ]:
0.85

[ Index of Refraction ]:
1.828

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

Guanosine
Acetone
2,2-Dimethoxypropane

DownStream

[2-(2-amino-6-oxo-3H-purin-9-yl)-7,7-dimethyl-3,6,8-trioxabicyclo[3.3.0]oct-4-yl]methylimino-imino-azanium
6-O-Methyl Guanosine
Guanosine
5'-Guanylic acid
GDP
N-(guanin-8-yl)-N-acetyl-2-aminofluorene
[2-(2-amino-6-oxo-3H-purin-9-yl)-7,7-dimethyl-3,6,8-trioxabicyclo[3.3.0]oct-4-yl]methyl acetate

Articles

Detection and identification of mutagens by the adducts formed upon reaction with guanosine derivatives.

IARC Sci. Publ. 70 , 413-418, (1986)

Mutagens present in crude samples such as heated glucose can be detected or identified by means of the adducts formed upon reaction with a fluorescent guanosine derivative (FG) or isopropylideneguanos...

Hydroxylation of guanine in nucleosides and DNA at the C-8 position by heated glucose and oxygen radical-forming agents.

Environ. Health Perspect. 67 , 111-116, (1986)

Heated glucose is mutagenic to Salmonella typhimurium TA 100 in the absence of S-9 mix. For identifying unknown mutagens in heated glucose (dry solid, 200 degrees C, 20 min), reaction with isopropylid...

Synthesis and application of a new 2',3'-isopropylidene guanosine substituted cap analog.

Bioorg. Med. Chem. Lett. 18 , 4828-4832, (2008)

The synthesis and biological evaluation of a new cap analog, which is modified at the C2' and C3' positions of N(7)-methylguanosine is reported. The new cap analog, P(1)-2',3'-isopropylidene, 7-methyl...

5'-azido-2',3'-O-isopropylideneguanosine
5'-azido-2',3'-O-isopropylideneguanosine
5'-O-tosyl-2',3'-O-isopropylideneguanosine
2-N-benzoyl-2',3'-O-isopropylideneguanosine
8-allylamino-2',3'-O-isopropylideneguanosine
2-N-propionyl-2',3'-O-isopropylideneguanosine
3-Amino-N-cyclopropyl-4-(4-morpholinyl)benzenesulfonamide
2-(ethylthio)-7-phenyl-3-(p-tolyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
benzyl N-{4-[(5-cyanopyridin-2-yl)oxy]cyclohexyl}carbamate
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
N-(9H-fluoren-2-yl)-4-methoxy-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide