Buspirone

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Names

[ CAS No. ]:
36505-84-7

[ Name ]:
Buspirone

[Synonym ]:
Ansial
8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro(4.5)-decane-7,9-dione
EINECS 253-072-2
Anxiron
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
MFCD00078569
Buspironum [INN-Latin]
Buspironum
Ansiced
Bespar
Buspirona [INN-Spanish]
[14C]-Buspirone
8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione
Buspirona

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
613.9ºC at 760 mmHg

[ Melting Point ]:
41678ºC

[ Molecular Formula ]:
C21H31N5O2

[ Molecular Weight ]:
385.50300

[ Flash Point ]:
325.1ºC

[ Exact Mass ]:
385.24800

[ PSA ]:
69.64000

[ LogP ]:
2.02900

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CL9910000
CHEMICAL NAME :
8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-
CAS REGISTRY NUMBER :
36505-84-7
BEILSTEIN REFERENCE NO. :
0964904
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H31-N5-O2
MOLECULAR WEIGHT :
385.57
WISWESSER LINE NOTATION :
T6VNV EXTJ B4- AT6N DNTJ D- BT6N CNJ&& E-& AL5XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human
DOSE/DURATION :
399 mg/kg/19D-I
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,409,1976

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
CL9915000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3,3-Tetramethyleneglutarimide
  • 8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane Bromide
  • 1-(2-PYRIMIDINYL) PIPERAZINE
  • 8-(4-Bromobutyl)-8-azaspiro[4.5]decane-7,9-dione
  • 8-[4-(4-pyrimidin-2-yl-piperazin-1-yl)but-2-enyl]-8-aza-spiro[4.5]decane-7,9-dione
  • 3,3-Tetramethyleneglutaric anhydride
  • 1-(2-Pyrimidinyl)-4-(4-aminobutyl)piperazine
  • 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]-2-butynyl]-8-azaspiro[4.5]decane-7,9-dione
  • 8-(prop-2-ynyl)-8-azaspiro[4.5]decane-7,9-dione
  • 1,4-Dibromobutane

DownStream

  • 6-HYDROXY BUSPIRONE

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Buspirone-d8
  • Buspirone N-oxide
  • 6-HYDROXY BUSPIRONE
  • 5-Hydroxy Buspirone
  • buspirone analogue,7
  • Buspirone Impurity 2
  • N-(3-chloro-4-methoxyphenyl)-2-[4-(5-phenyl-1,2,4-oxadiazol-3-yl)-1H-imidazol-1-yl]acetamide
  • I(2)-Alanine, N-[2-(4-chlorophenoxy)-1-oxopropyl]-N-(phenylmethyl)-, ethyl ester
  • N~1~-(4-methylbenzyl)-2-{4-[5-(3-pyridyl)-1,2,4-oxadiazol-3-yl]-1H-imidazol-1-yl}acetamide
  • Acetamide, N-[3-chloro-4-(1-piperidinyl)phenyl]-2-methoxy-
  • 3-Ethoxy-N-(prop-2-yn-1-yl)benzamide
  • N-(4-methoxyphenyl)-2-{4-[5-(pyridin-3-yl)-1,2,4-oxadiazol-3-yl]-1H-imidazol-1-yl}acetamide
  • 4-phenyl-N-(3-piperidyl)butanamide
  • N-(tert-butyl)-2-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide
  • N-(5-ethyl-3,3-dimethyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-8-yl)-2-methoxy-4,5-dimethylbenzenesulfonamide
  • N-(5-ethyl-3,3-dimethyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-8-yl)propane-2-sulfonamide
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