Buspirone

Suppliers

Names

[ Name ]:
Buspirone

[Synonym ]:
Ansial
8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro(4.5)-decane-7,9-dione
EINECS 253-072-2
Anxiron
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
MFCD00078569
Buspironum [INN-Latin]
Buspironum
Ansiced
Bespar
Buspirona [INN-Spanish]
[14C]-Buspirone
8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione
Buspirona

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
613.9ºC at 760 mmHg

[ Melting Point ]:
41678ºC

[ Molecular Formula ]:
C₂₁H₃₁N₅O₂

[ Molecular Weight ]:
385.50300

[ Flash Point ]:
325.1ºC

[ Exact Mass ]:
385.24800

[ PSA ]:
69.64000

[ LogP ]:
2.02900

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CL9910000

CHEMICAL NAME :: 8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-

CAS REGISTRY NUMBER :: 36505-84-7

BEILSTEIN REFERENCE NO. :: 0964904

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H31-N5-O2

MOLECULAR WEIGHT :: 385.57

WISWESSER LINE NOTATION :: T6VNV EXTJ B4- AT6N DNTJ D- BT6N CNJ&& E-& AL5XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human

DOSE/DURATION :: 399 mg/kg/19D-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,409,1976

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
CL9915000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3,3-Tetramethyleneglutarimide
8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane Bromide
1-(2-PYRIMIDINYL) PIPERAZINE
8-(4-Bromobutyl)-8-azaspiro[4.5]decane-7,9-dione
8-[4-(4-pyrimidin-2-yl-piperazin-1-yl)but-2-enyl]-8-aza-spiro[4.5]decane-7,9-dione
3,3-Tetramethyleneglutaric anhydride
1-(2-Pyrimidinyl)-4-(4-aminobutyl)piperazine
8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]-2-butynyl]-8-azaspiro[4.5]decane-7,9-dione
8-(prop-2-ynyl)-8-azaspiro[4.5]decane-7,9-dione
1,4-Dibromobutane

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%