Buspirone
Buspirone structure
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Common Name | Buspirone | ||
|---|---|---|---|---|
| CAS Number | 36505-84-7 | Molecular Weight | 385.50300 | |
| Density | 1.24g/cm3 | Boiling Point | 613.9ºC at 760 mmHg | |
| Molecular Formula | C21H31N5O2 | Melting Point | 41678ºC | |
| MSDS | N/A | Flash Point | 325.1ºC | |
Use of BuspironeBuspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | buspirone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Buspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Buspirone (0-400 µg/mL; 6 hours) has cytotoxic effect in Lymphocytes[1].Buspirone (0-180 µg/mL; 0-3 hours; Lymphocytes)induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG)[1]. Cell Viability Assay[1] Cell Line: Lymphocytes Concentration: 0, 4, 20, 40, 200 and 400 µg/mL Incubation Time: 6 hours Result: Decreased cell viability in a dose-dependent manner. |
| In Vivo | Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors[2]. Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota[2]. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced the IS- or EC-induced gut Proteobacteria population. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.24g/cm3 |
|---|---|
| Boiling Point | 613.9ºC at 760 mmHg |
| Melting Point | 41678ºC |
| Molecular Formula | C21H31N5O2 |
| Molecular Weight | 385.50300 |
| Flash Point | 325.1ºC |
| Exact Mass | 385.24800 |
| PSA | 69.64000 |
| LogP | 2.02900 |
| InChIKey | QWCRAEMEVRGPNT-UHFFFAOYSA-N |
| SMILES | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1 |
| Storage condition | 2-8°C |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 1 | |
CAS#:1075-89-4![8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane Bromide Structure](https://image.chemsrc.com/caspic/372/81461-73-6.png)
CAS#:81461-73-6
CAS#:20980-22-7![8-(4-Bromobutyl)-8-azaspiro[4.5]decane-7,9-dione Structure](https://image.chemsrc.com/caspic/016/80827-62-9.png)
CAS#:80827-62-9![8-[4-(4-pyrimidin-2-yl-piperazin-1-yl)but-2-enyl]-8-aza-spiro[4.5]decane-7,9-dione Structure](https://image.chemsrc.com/caspic/220/118286-98-9.png)
CAS#:118286-98-9
CAS#:5662-95-3
CAS#:33386-20-8![8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]-2-butynyl]-8-azaspiro[4.5]decane-7,9-dione Structure](https://image.chemsrc.com/caspic/258/118286-97-8.png)
CAS#:118286-97-8![8-(prop-2-ynyl)-8-azaspiro[4.5]decane-7,9-dione Structure](https://image.chemsrc.com/caspic/254/25032-23-9.png)
CAS#:25032-23-9
CAS#:110-52-1
CAS#:125481-61-0This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Ansial |
| 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro(4.5)-decane-7,9-dione |
| EINECS 253-072-2 |
| Anxiron |
| 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione |
| MFCD00078569 |
| Buspironum [INN-Latin] |
| Buspironum |
| Ansiced |
| Bespar |
| Buspirona [INN-Spanish] |
| [14C]-Buspirone |
| 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione |
| Buspirona |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of buspirone? |
| A: CAS number of buspirone is 36505-84-7. |
| Q: What is the melting point of buspirone? |
| A: Melting point of buspirone is 41678ºC. |
| Q: What are the upstream materials of buspirone? |
| A: Related upstream materials(CAS) of buspirone: 1075-89-4;81461-73-6;20980-22-7;80827-62-9;118286-98-9;5662-95-3;33386-20-8;118286-97-8;25032-23-9;110-52-1. |
| Q: What is the English name of buspirone? |
| A: The English name of buspirone is buspirone. |
| Q: What are the uses of buspirone? |
| A: Main uses of buspirone: Buspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2]. |
| Q: What is the boiling point of buspirone? |
| A: Boiling point of buspirone is 613.9ºC at 760 mmHg. |
| Q: What is the molecular weight of buspirone? |
| A: Molecular weight of buspirone is 385.50300. |
| Q: What is the polar surface area (PSA) of buspirone? |
| A: Polar surface area (PSA) of buspirone is 69.64000. |
| Q: What is the molecular formula of buspirone? |
| A: Molecular formula of buspirone is C21H31N5O2. |
| Q: What is the safety information for buspirone? |
| A: Safety information for buspirone: S45. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |