Buspirone

Modify Date: 2024-01-02 13:43:33

Buspirone Structure
Buspirone structure
Common Name Buspirone
CAS Number 36505-84-7 Molecular Weight 385.50300
Density 1.24g/cm3 Boiling Point 613.9ºC at 760 mmHg
Molecular Formula C21H31N5O2 Melting Point 41678ºC
MSDS N/A Flash Point 325.1ºC

 Use of Buspirone


Buspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2].

 Names

Name buspirone
Synonym More Synonyms

 Buspirone Biological Activity

Description Buspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2].
Related Catalog
In Vitro Buspirone (0-400 µg/mL; 6 hours) has cytotoxic effect in Lymphocytes[1].Buspirone (0-180 µg/mL; 0-3 hours; Lymphocytes)induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG)[1]. Cell Viability Assay[1] Cell Line: Lymphocytes Concentration: 0, 4, 20, 40, 200 and 400 µg/mL Incubation Time: 6 hours Result: Decreased cell viability in a dose-dependent manner.
In Vivo Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors[2]. Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota[2]. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced the IS- or EC-induced gut Proteobacteria population.
References

[1]. Salimi A, et, al. Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model. Curr Clin Pharmacol. 2018;13(2):120-127.

[2]. Kim JK, et, al. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11(1):6094.

 Chemical & Physical Properties

Density 1.24g/cm3
Boiling Point 613.9ºC at 760 mmHg
Melting Point 41678ºC
Molecular Formula C21H31N5O2
Molecular Weight 385.50300
Flash Point 325.1ºC
Exact Mass 385.24800
PSA 69.64000
LogP 2.02900
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CL9910000
CHEMICAL NAME :
8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-
CAS REGISTRY NUMBER :
36505-84-7
BEILSTEIN REFERENCE NO. :
0964904
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H31-N5-O2
MOLECULAR WEIGHT :
385.57
WISWESSER LINE NOTATION :
T6VNV EXTJ B4- AT6N DNTJ D- BT6N CNJ&& E-& AL5XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human
DOSE/DURATION :
399 mg/kg/19D-I
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,409,1976

 Safety Information

Hazard Codes T: Toxic;
Risk Phrases R25
Safety Phrases S45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS CL9915000
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Ansial
8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro(4.5)-decane-7,9-dione
EINECS 253-072-2
Anxiron
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
MFCD00078569
Buspironum [INN-Latin]
Buspironum
Ansiced
Bespar
Buspirona [INN-Spanish]
[14C]-Buspirone
8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione
Buspirona