4-hydroxyisobenzofuran-1,3-dione

Names

[ Name ]:
4-hydroxyisobenzofuran-1,3-dione

[Synonym ]:
MFCD00011557
3-Hydroxyphthalic anhydride
4-Hydroxyisobenzofuran-1,3-dione
4-Hydroxy-2-benzofuran-1,3-dione
1,3-Isobenzofurandione, 4-hydroxy-
4-Hydroxy-isobenzofuran-1,3-dione

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
365.4±25.0 °C at 760 mmHg

[ Melting Point ]:
199-202 °C(lit.)

[ Molecular Formula ]:
C₈H₄O₄

[ Molecular Weight ]:
164.12

[ Flash Point ]:
160.2±16.7 °C

[ Exact Mass ]:
164.010956

[ PSA ]:
63.60000

[ LogP ]:
0.86

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.666

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI3300000

CHEMICAL NAME :: Phthalic anhydride, 3-hydroxy-

CAS REGISTRY NUMBER :: 37418-88-5

BEILSTEIN REFERENCE NO. :: 0135783

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H4-O4

MOLECULAR WEIGHT :: 164.12

WISWESSER LINE NOTATION :: T56 BVOVJ FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#08845

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TI3300000

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-(2,2-dimethylpropanoyloxy-3,5)-dioxo-exo-10-oxatricyclo[5.2.1.02.6]dec-8-ene
3-Hydroxyphthalic acid
5-Methoxy-1-naphthalenol
1,5-Dihydroxynaphthalene
3-Methoxyphthalic acid
1-methoxy-7-oxa-norborn-5-ene-2,3-dicarboxylic acid-anhydride
Hydrogen bromide
acetic acid

DownStream

3-butylidene-4-hydroxy-2-benzofuran-1-one
4-Methoxy-2-benzofuran-1,3-dione
1-HYDROXYANTHRAQUINONE
(1,3-dioxo-2-benzofuran-4-yl) acetate
3-Methoxyphthalic acid
dimethyl 3-hydroxyphthalate
9,10-Anthracenedione,1,4,5-trihydroxy-
3-bromo-4-methoxy-3H-2-benzofuran-1-one
o-xylene-3,alpha,alpha'-triol
1,8-DIHYDROXY-2-METHOXY-3-METHYL-ANTHRAQUINONE

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The antiviral activity of naturally occurring proteins and their peptide fragments after chemical modification.

Antiviral Res. 59(1) , 23-33, (2003)

Chemical modification of the proteins bovine serum albumin, alpha-lactalbumin, beta-lactoglobulin and chicken lysozyme by 3-hydroxyphthalic anhydride (3-HP) yielded compounds which exerted antiviral a...

[Antiviral activity of 3-hydroxyphthalic anhydride-modified ovalbumin against herpes simplex virus 2 in vitro].

Nan Fang Yi Ke Da Xue Xue Bao 31(7) , 1175-8, (2011)

To investigate the antiviral activity of 3-hydroxyphthalic anhydride-modified ovalbumin (HP-OVA) against herpes simplex virus 2 (HSV-2) in vitro.By chemical modification, ovalbumin (OVA) was treated w...

3-hydroxyphthalic anhydride-modified chicken ovalbumin exhibits potent and broad anti-HIV-1 activity: a potential microbicide for preventing sexual transmission of HIV-1.

Antimicrob. Agents Chemother. 54(5) , 1700-11, (2010)

Heterosexual transmission is the primary route by which women acquire human immunodeficiency virus (HIV)/AIDS. Thus, development of woman-controlled topical microbicides for prevention of sexual trans...