W-2429

Suppliers

Names

[ CAS No. ]:
37795-69-0

[ Name ]:
W-2429

[Synonym ]:
W 2429
2,3-dihydro-9H-isoxazolo<3,2-b>quinazolin-9-one
W-2429

Chemical & Physical Properties

[ Density]:
1.47g/cm3

[ Boiling Point ]:
330ºC at 760mmHg

[ Molecular Formula ]:
C10H8N2O2

[ Molecular Weight ]:
188.18300

[ Flash Point ]:
153.4ºC

[ Exact Mass ]:
188.05900

[ PSA ]:
44.12000

[ LogP ]:
0.38120

[ Index of Refraction ]:
1.719

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NY3450000
CHEMICAL NAME :
9H-Isoxazolo(3,2-b)quinazolin-9-one, 2,3-dihydro-
CAS REGISTRY NUMBER :
37795-69-0
LAST UPDATED :
199706
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C10-H8-N2-O2
MOLECULAR WEIGHT :
188.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
395 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
278 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
212 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg/30D-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3 gm/kg/30D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • METHYL 2-[(3-CHLOROPROPANOYL)AMINO]BENZOATE
  • Methyl 2-aminobenzoate
  • Isatoic anhydride
  • 3-Chloropropanoyl chloride
  • Isoxazolidin-3-one

DownStream

  • [1,2]oxazolo[3,2-b]quinazolin-9-one

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • W(CH-t-Bu)(N-2,6-diisopropylphenyl)(hexafluoro-tert-butoxide)2
  • W(CO)3(η6-Me6C6)
  • W(CO)5(4-cyanopyridine)
  • W(CO)5(triphenylphosphite)
  • [W(η(5)-C5H5)(CO)2(N:CBu(t)2)]
  • [W(CO)4(2-(diphenylphosphinoamino)pyridine)]
  • 4-Amino-3-(3-methoxy-4-methylphenyl)butanoic acid
  • 4-Amino-3-(3-methoxy-2-methylphenyl)butanoic acid
  • Heptatetracontanoic acid
  • N,N-Dimethyl-5-[[methyl(prop-2-ynyl)amino]methyl]pyrimidin-2-amine
  • 6-Bromo-n2-methylpyridine-2,3-diamine
  • 2-[(2-Bromo-3-fluorophenyl)methyl]pyrrolidine
  • 1-[(1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decan-4-yl]-2-methylpropan-1-one
  • 4-(2,2-Dimethylpropyl)-1-iodo-2-nitrobenzene
  • 1-(8-Chloro-5-formylisoquinolin-3-yl)-3-ethylurea
  • 10-Aminodecanoic acid hydrochloride salt
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