W-2429

Modify Date: 2025-08-27 17:12:49

W-2429 structure	Common Name	W-2429
	CAS Number	37795-69-0	Molecular Weight	188.18300
	Density	1.47g/cm3	Boiling Point	330ºC at 760mmHg
	Molecular Formula	C₁₀H₈N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	153.4ºC

Use of W-2429

W-2429 is a non-narcotic analgesic agent.

Name	2,3-dihydro-[1,2]oxazolo[3,2-b]quinazolin-9-one
Synonym	More Synonyms

Description	W-2429 is a non-narcotic analgesic agent.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	W-2429 is a non-narcotic analgesic agent. Treatment with W-2429 is well tolerated by rats as well as dogs. In the dog, the only signs of toxicity observed are decreased appetite and salivation at 100 mg/kg/day W-2429. No other significant evidence of physical, chemical, gross or histopathologic change is observed[1].
References	[1]. Banerjee BN, et al. Toxicological investigation of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429). Acuteand subacute toxicity in mice, rats and dogs. Arzneimittelforschung. 1977;27(4):793-801.

Density	1.47g/cm3
Boiling Point	330ºC at 760mmHg
Molecular Formula	C₁₀H₈N₂O₂
Molecular Weight	188.18300
Flash Point	153.4ºC
Exact Mass	188.05900
PSA	44.12000
LogP	0.38120
Index of Refraction	1.719
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY3450000

CHEMICAL NAME :: 9H-Isoxazolo(3,2-b)quinazolin-9-one, 2,3-dihydro-

CAS REGISTRY NUMBER :: 37795-69-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H8-N2-O2

MOLECULAR WEIGHT :: 188.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 278 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 212 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg/30D-C

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3 gm/kg/30D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977

HS Code	2934999090

METHYL 2-[(3-CH...

CAS#:37795-76-9

W-2429

CAS#:37795-69-0

Literature: Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770

Methyl 2-aminob...

CAS#:134-20-3

W-2429

CAS#:37795-69-0

Literature: Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770

Isatoic anhydride

CAS#:118-48-9

3-Chloropropano...

CAS#:625-36-5

W-2429

CAS#:37795-69-0

Literature: Dunn, A. D.; Kinnear, K. I.; Norrie, R.; Ringan, N.; Martin, D. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 175 - 180

Isoxazolidin-3-one

CAS#:1192-07-0

Isatoic anhydride

CAS#:118-48-9

W-2429

CAS#:37795-69-0

Literature: Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770

Precursor 5
CAS#:37795-76-9 METHYL 2-[(3-CH... CAS#:134-20-3 Methyl 2-aminob... CAS#:118-48-9 Isatoic anhydride CAS#:625-36-5 3-Chloropropano...
CAS#:1192-07-0 Isoxazolidin-3-one
DownStream 1
CAS#:63480-08-0 [1,2]oxazolo[3,...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

W 2429

2,3-dihydro-9H-isoxazolo<3,2-b>quinazolin-9-one

W-2429

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W-2429

Use of W-2429

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W-2429 Biological Activity

Chemical & Physical Properties

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.