Tyrphostin 8

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Names

[ CAS No. ]:
3785-90-8

[ Name ]:
Tyrphostin 8

[Synonym ]:
4-(HYDROXYBENZYLIDENE)-MALONONITRILE
4-Hydroxybenzylidenemalononitrile
(4-Hydroxybenzylidene)malonitrile
EINECS 223-253-0
2-[(4-hydroxyphenyl)methylidene]propanedinitrile
MFCD00020189

Chemical & Physical Properties

[ Density]:
1.29 g/cm3

[ Boiling Point ]:
354.3ºC at 760 mmHg

[ Melting Point ]:
186-189 °C

[ Molecular Formula ]:
C10H6N2O

[ Molecular Weight ]:
170.17

[ Flash Point ]:
168.1ºC

[ Exact Mass ]:
170.04800

[ PSA ]:
67.81000

[ LogP ]:
1.82276

[ Index of Refraction ]:
1.653

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 20 mg/mL, clear

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OO4200000
CHEMICAL NAME :
Malononitrile, (p-hydroxybenzylidene)-
CAS REGISTRY NUMBER :
3785-90-8
BEILSTEIN REFERENCE NO. :
2209079
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H6-N2-O
MOLECULAR WEIGHT :
170.18
WISWESSER LINE NOTATION :
QR D1UYCN&CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 14,1325,1965
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 228,1315,1970

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319

[ Precautionary Statements ]:
P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
25

[ Safety Phrases ]:
S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
OO4200000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-hydroxybenzaldehyde
  • Malononitrile
  • N-(p-hydroxybenzylidene)-p-aminoacetophenone
  • 2-(phenoxymethylidene)propanedinitrile
  • POTASSIUMPHENOLATE
  • 1-Naphthalenol

DownStream

  • AG 43
  • [4-(2,2-dicyanoethenyl)phenyl] acetate
  • 2-cyano-3-(4-hydroxyphenyl)prop-2-enamide
  • 4-(1H-BENZOIMIDAZOL-2-YL)-PHENOL
  • [4-(2,2-dicyanoethenyl)phenyl] 4-heptanoyloxybenzoate

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Effect of combined changes in delayed extraction time and potential gradient on the mass resolution and ion discrimination in the analysis of polydisperse polymers and polymer blends by delayed extraction matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Rapid Commun. Mass Spectrom. 13(24) , 2511-7, (1999)

Data reported here show that, in the delayed extraction matrix-assisted laser desorption/ionization time-of-flight (DE-MALDI-TOF) mass spectrometric analysis of synthetic polydisperse polymers, differ...

[Prevalence of Aeromonas spp. pediatric gastroenteritis].

CMAJ 138(8) , 714-7, (1988)

A selective medium and biochemical tests were used to search for Aeromonas spp. in the stools of 536 children, more than 90% of whom had "gastroenteritis", seen at Sainte-Justine Hospital, Montreal, i...

Characterization and modulation of the transferrin receptor on brain capillary endothelial cells.

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The expression level of the transferrin receptor (TfR) on brain capillary endothelial cells (BCECs) and the endocytosis of 125I-transferrin (125I-Tf) by this receptor was investigated. Furthermore, th...


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Related Compounds

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  • 1-(8,9-dimethoxy-4,4-dioxo-5,6-dihydro-4H-4λ6-naphtho[2,1-c][1,2]oxathiin-2-yl)-pyrrolidin-2-one
  • (5,8-dimethylquinolin-4-yl)hydrazine,hydrochloride
  • 4,8-dimethylnonan-2-one
  • 5,8-dimethoxy-4-oxo-2,3-dihydro-1H-naphthalene-2-carboxylic acid
  • 6,8-Dioxabicyclo3.2.1octane, 2-(cyclohexylmethoxy)-4-methoxy-5-propyl-, 1R-(exo,exo)-
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • Ethyl 2-chloro-4-(1H-pyrazol-1-yl)benzoate
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide