Tyrphostin 8
Tyrphostin 8 structure
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Common Name | Tyrphostin 8 | ||
|---|---|---|---|---|
| CAS Number | 3785-90-8 | Molecular Weight | 170.17 | |
| Density | 1.29 g/cm3 | Boiling Point | 354.3ºC at 760 mmHg | |
| Molecular Formula | C10H6N2O | Melting Point | 186-189 °C | |
| MSDS | Chinese USA | Flash Point | 168.1ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Effect of combined changes in delayed extraction time and potential gradient on the mass resolution and ion discrimination in the analysis of polydisperse polymers and polymer blends by delayed extraction matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Rapid Commun. Mass Spectrom. 13(24) , 2511-7, (1999) Data reported here show that, in the delayed extraction matrix-assisted laser desorption/ionization time-of-flight (DE-MALDI-TOF) mass spectrometric analysis of synthetic polydisperse polymers, different experimental conditions of spectral recording are requi... |
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[Prevalence of Aeromonas spp. pediatric gastroenteritis].
CMAJ 138(8) , 714-7, (1988) A selective medium and biochemical tests were used to search for Aeromonas spp. in the stools of 536 children, more than 90% of whom had "gastroenteritis", seen at Sainte-Justine Hospital, Montreal, in June or July 1986. The organism was found in seven childr... |
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Characterization and modulation of the transferrin receptor on brain capillary endothelial cells.
Pharm. Res. 21(5) , 761-9, (2004) The expression level of the transferrin receptor (TfR) on brain capillary endothelial cells (BCECs) and the endocytosis of 125I-transferrin (125I-Tf) by this receptor was investigated. Furthermore, the influence of iron, the iron scavenger deferoxamine mesyla... |
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Local delivery of platelet-derived growth factor receptor-specific tyrphostin inhibits neointimal formation in rats.
Arterioscler. Thromb. Vasc. Biol. 20(3) , 667-76, (2000) Signal transduction through the platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) system is involved in the process of postangioplasty restenosis. Tyrphostins are low molecular weight inhibitors of protein tyrosine kinases. We assessed the antiproli... |
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Multiple effects of staurosporine, a kinase inhibitor, on thymocyte functions. Comparison with the effect of tyrosine kinase inhibitors.
Biochem. Pharmacol. 44(8) , 1563-8, (1992) The effects of staurosporine, a protein kinase inhibitor, on the signal transduction and proliferation of thymocytes were studied. Signal transduction in response to Concanavalin A (Con A) as well as Concanavalin A (Con A)-induced augmentation of [3H]inositol... |
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Interleukin-1 induces protein tyrosine phosphorylation in T cells.
Eur. J. Immunol. 22(6) , 1391-6, (1992) Interleukin (IL)-1 alpha activates multiple signal transmission pathways in the T helper type 2 cell line, D10A, and these pathways are linked to two separate IL-1 receptors (IL-1R). In the present report we show that IL-1 induces the activation of tyrosine k... |
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Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats.
Pharm. Res. 18(2) , 191-5, (2001) To investigate the effect of tyrphostin 8 (T-8), a GTPase inhibitor, on transferrin receptor (TfR)-mediated transcytosis of insulin-transferrin (In-Tf) conjugate in cultured enterocyte-like Caco-2 cells and on gastrointestinal (GI) absorption of In-Tf in stre... |