3,4-Difluoroaniline

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Names

[ CAS No. ]:
3863-11-4

[ Name ]:
3,4-Difluoroaniline

[Synonym ]:
3,4-fluoroaniline
ZR CF DF
3',4'-difluoroaniline
Benzenamine, 3,4-difluoro-
EINECS 223-381-7
3,4-Difluoroaniline
3,4-difluoro-benzenamin
3,4-difluorophenylamine
3,4-difluoraniline
Benzenamine,3,4-difluoro
3,4-Difluorobenzenamine
MFCD00007761

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
205.0±0.0 °C at 760 mmHg

[ Melting Point ]:
22°C

[ Molecular Formula ]:
C6H5F2N

[ Molecular Weight ]:
129.107

[ Flash Point ]:
85.0±0.0 °C

[ Exact Mass ]:
129.039001

[ PSA ]:
26.02000

[ LogP ]:
1.51

[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.521

[ Water Solubility ]:
SLIGHTLY SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CX9871900
CHEMICAL NAME :
Benzenamine, 3,4-difluoro-
CAS REGISTRY NUMBER :
3863-11-4
BEILSTEIN REFERENCE NO. :
0971235
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H5-F2-N

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
340 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),31,1993
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10720 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),31,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),31,1993

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39

[ RIDADR ]:
UN 2941 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
CX9871900

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3,4-Difluoronitrobenzene
  • Iron
  • Benzamide,3,4-difluoro-
  • p-Chlorobenzotrichloride
  • 4-chloro-3-chlorosulfonyl-benzoic acid
  • 4-Chloro-3-(chlorosulfonyl)benzoyl chloride
  • Benzoyl fluoride, 3,4-difluoro- (9CI)
  • 4-Fluoroaniline

DownStream

  • 1-(3,4-difluorophenyl)-7,7-dimethyl-3-[(3-nitrophenyl)methyl]-6,8-dihydroquinoline-2,5-dione
  • 3,4-Difluoro thiophenol
  • Tert-butyln-(3,4-difluorophenyl)carbamate
  • 3,4-Difluorophenyl isocyanate
  • N-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYLPROPIONAMIDE
  • Propanoic acid-4,5-difluoro-1H-indole (1:1)
  • Ethyl 5,6-difluoro-1H-indole-2-carboxylate
  • 4,5-DIBROMO-2-(3,4-DIFLUOROPHENYL)-3(2H)-PYRIDAZINONE
  • Carbamic acid,(3,4-difluorophenyl)-, ethyl ester (9CI)

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Degradation of 3,4-dichloro- and 3,4-difluoroaniline by Pseudomonas fluorescens 26-K.

J. Environ. Sci. Health B 38(2) , 121-32, (2003)

3,4-Dichloro- and 3,4-difluoroanilines were degraded by Pseudomonas fluorescens 26-K under aerobic conditions. In the presence of glucose strain degraded 170 mg/L of 3,4-dichloroaniline (3,4-DCA) duri...

Synthesis and theoretical studies on the vibration of a novel (3,4-disfluoro)phenylquione.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 73(1) , 96-100, (2009)

A novel (3,4-disfluoro)phenylquione (2F-PQ) was synthesized through the reaction of 3,4-Difluoroaniline and 1,4-benzoquinone. Its structure was verified by (1)H NMR, FTIR and Raman spectra. The ground...


More Articles

Related Compounds

  • 3,4-Difluoroaniline-d2
  • 2-Bromo-3,4-difluoroaniline
  • 2-nitro-3,4-difluoroaniline
  • N-Ethyl-3,4-difluoroaniline
  • 2-Chloro-3,4-difluoroaniline
  • 2-BUTOXY-3,4-DIFLUOROANILINE
  • 4-Bromo-7-methylthieno[3,2-d]pyrimidine
  • 1-(Bromomethyl)-1-(isobutoxymethyl)cyclopropane
  • Bz-Val-Gly-Arg-AMC trifluoroacetate
  • (S)-Methyl 3-amino-4-phenylbutanoate hydrochloride
  • trans-2-(2,5-Dimethylphenoxy)cyclopentan-1-ol
  • 1-(Bromomethyl)-1-[(propan-2-yloxy)methyl]cyclopropane
  • (1R,2R)-2-(3,4-dimethylphenoxy)cyclopentan-1-ol
  • 1-(Pyridin-4-YL)octan-1-amine
  • 3-Amino-4-(2-chlorophenyl)-1-(4-ethylphenyl)azetidin-2-one
  • 2-methanesulfinyl-4-(1-methyl-1H-pyrazol-4-yl)-pyrimidine
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