4-Trifluoromethylphenol

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Names

[ CAS No. ]:
402-45-9

[ Name ]:
4-Trifluoromethylphenol

[Synonym ]:
4-Trifluoromethylphenol
4-(Trifluormethyl)benzolol
P-Trifluoromethylphenol
4-(Trifluoromethyl)phenol
α,α,α-Trifluoro-p-cresol
Phenol, 4-(trifluoromethyl)-
4-Hydroxybenzotrifluoride
4-(Trifluoromethyl)-phenol
4-Hydroxy-α,α,α-trifluorotoluene
MFCD00002363
alpha,alpha,alpha-Trifluoro-p-cresol
EINECS 206-945-7

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
185.5±35.0 °C at 760 mmHg

[ Melting Point ]:
45-47 °C(lit.)

[ Molecular Formula ]:
C7H5F3O

[ Molecular Weight ]:
162.109

[ Flash Point ]:
80.1±20.4 °C

[ Exact Mass ]:
162.029251

[ PSA ]:
20.23000

[ LogP ]:
2.82

[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.458

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H228-H301-H315-H318-H335

[ Precautionary Statements ]:
P210-P261-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S39-S24/25

[ RIDADR ]:
UN 2926 4.1/PG 2

[ WGK Germany ]:
3

[ HS Code ]:
2907299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Trifluoromethylphenylboronic acid
  • 4-Bromobenzotrifluoride
  • 4-Chlorobenzotrifluoride
  • iso-propoxydimethyl(4-(trifluoromethyl)phenyl)silane
  • 4-Hydroxyphenylboronic acid
  • Sodium trifluoromethanesulphinate
  • Carbon dioxide
  • 4-(TRIFLUOROMETHYL)PHENYL TRIFLUOROMETHANESULFONATE
  • [p-(trifluoromethyl)phenyl]dimethylsilane

DownStream

  • 4-Trifluoromethylsalicylic acid
  • 3,5-Dibromo-4-hydroxybenzoic acid
  • 2-Chloro-4-(trifuloromethyl)phenol
  • 4-hydroxy-4-(trifluoromethyl)-2,5-cyclohexadien-1-one
  • 2-chloro-4-hydroxy-4-trifluoromethylcyclohexa-2,5-dienone
  • 2-chloro-3,3,3-trifluoropropanoic acid
  • 3-BROMO-4-METHOXYBENZOTRIFLUORIDE
  • 4-[(4-TRIFLUOROMETHYL)PHENOXY]PHENOL
  • 2-Amino-4-(trifluoromethyl)phenol
  • 4-(TRIFLUOROMETHYL)PHENYL TRIFLUOROMETHANESULFONATE

Customs

[ HS Code ]: 2908199090

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

Articles

Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes.

Chem. Commun. (Camb.) (39) , 4780-2, (2008)

A high yielding, batch mode synthesis of diaryl ethers and sulfides by an S(N)Ar fluoride-mediated process in scCO(2) has been developed; the use of a polymer-supported imidazolium fluoride reagent in...

Structural analysis of flavinylation in vanillyl-alcohol oxidase.

J. Biol. Chem. 275(49) , 38654-8, (2000)

Vanillyl-alcohol oxidase (VAO) is member of a newly recognized flavoprotein family of structurally related oxidoreductases. The enzyme contains a covalently linked FAD cofactor. To study the mechanism...

Simultaneous determination of fluoxetine and its metabolite p-trifluoromethylphenol in human liver microsomes using a gas chromatographic-electron-capture detection procedure.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 769(2) , 305-11, (2002)

An gas chromatography-electron-capture detection method has been developed for simultaneous determination of fluoxetine and p-trifluoromethylphenol (TFMP), an O-dealkylated metabolite of fluoxetine in...


More Articles

Related Compounds

  • 3-amino-4-trifluoromethylphenol
  • 3-nitro-4-trifluoromethylphenol
  • 3-nitro-4-trifluoromethylphenol
  • 3-bromo-4-trifluoromethylphenol
  • 2-amino-4-trifluoromethylphenol
  • 3-methyl-4-trifluoromethylphenol
  • N-{[5-(2,4-difluorophenyl)-1,2-oxazol-3-yl]methyl}-1-(prop-2-enoyl)piperidine-4-carboxamide
  • (S)-2-(1-Acryloylpiperidine-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
  • 1-(4-{1-Azaspiro[3.3]heptane-1-carbonyl}piperidin-1-yl)prop-2-en-1-one
  • N-[1-cyano-2-(dimethylamino)-1-methylethyl]-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
  • N-(Cyanomethyl)-N-(4-fluoro-2-methylphenyl)-3-thiophen-2-ylpropanamide
  • 2-(2,2-Dimethyl-3,5-dihydro-1,4-benzoxazepin-4-yl)ethyl-ethylcyanamide
  • 2-Ethyl-5-iodo-1,3-dimethylbenzene
  • 6-Chloro-N-[[1-[(1-cyanocyclopropyl)methyl]triazol-4-yl]methyl]pyridine-3-carboxamide
  • methyl 1H,4H,5H,6H,7H-pyrazolo[3,4-b]pyridine-5-carboxylate
  • 2-Chloro-1-((3aR,6aR)-3a-(3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propan-1-one
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