5-Fluoronicotinic acid

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Names

[ CAS No. ]:
402-66-4

[ Name ]:
5-Fluoronicotinic acid

[Synonym ]:
MFCD01318537
Nicotinic acid, 5-fluoro-
T6NJ CVQ EF
5-Fluoronicotinic acid
5-Fluoropyridine-3-carboxylic acid
5-Fluoro-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 5-fluoro-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
272.2±20.0 °C at 760 mmHg

[ Melting Point ]:
199 °C

[ Molecular Formula ]:
C6H4FNO2

[ Molecular Weight ]:
141.100

[ Flash Point ]:
118.4±21.8 °C

[ Exact Mass ]:
141.022614

[ PSA ]:
50.19000

[ LogP ]:
0.41

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.542

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US5745250
CHEMICAL NAME :
3-Pyridinecarboxylic acid, 5-fluoro-
CAS REGISTRY NUMBER :
402-66-4
LAST UPDATED :
199806
DATA ITEMS CITED :
1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3737542

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
US5745250

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,6-Dichloro-5-fluoronicotinic acid
  • 4-chloro-5-fluoropyridine-3-carboxylic acid
  • 3-fluoro-5-iodo-2-(trimethylsilyl)pyridine
  • Carbon dioxide
  • ISOPROPYLMAGNESIUM CHLORIDE
  • 3-Fluoro-5-picoline
  • 3-Fluoropyridine
  • 4-Chloro-3-fluoropyridine
  • 3-Amino-5-methylpyridine
  • 3,5-Dimethylpyridine

DownStream

  • Methyl5-fluoropyridine-3-carboxylate
  • 5-Fluoronicotinaldehyde
  • 3-Pyridinecarboxamide,5-fluoro-
  • 5-Fluoronicotinoyl chloride
  • 1-(5-fluoropyridin-3-yl)ethanone
  • 5-fluoro-6-hydroxynicotinic acid
  • (5-Fluoro-3-pyridinyl)methanol
  • 5-Fluoropyridin-3-amine

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives.

Chem. Pharm. Bull. 35(6) , 2280-5, (1987)

Hydrophobic chromatography and bioanalysis of some polar pyridine derivatives used as antilipolytic agents.

J. Chromatogr. A. 187(1) , 189-98, (1980)

The antilipolytic compound 5-fluoro-3-pyridinecarboxylic acid and 5-fluoro-3-hydroxymethylpyridine have been determined quantitatively in plasma (Srel = 5-7% in the concentration range 1-20 microgram/...


More Articles

Related Compounds

  • 6-Bromo-5-fluoronicotinic acid
  • 2-BROMO-5-FLUORONICOTINIC ACID
  • 2-Amino-5-fluoronicotinic acid
  • 6-chloro-5-fluoronicotinic acid
  • 2-Chloro-5-fluoronicotinic acid
  • 4-BORONO-5-FLUORONICOTINIC ACID
  • 2-Amino-3-ethoxybenzonitrile
  • 1-methyl-3-pentyl-imidazol-1-ium;acetate
  • (S)-1-(Benzyloxy)hexan-3-ol
  • 6-Chloro-2-methoxy-3-methylpyridine
  • 1-[2-(Propan-2-yl)-1,3-oxazol-5-yl]methanamine
  • 2-Amino-1-(4-methylpyridin-3-yl)ethan-1-one
  • Methyl 3-(2-fluoro-4-hydroxyphenyl)-3-oxopropanoate
  • 3-(3-Bromopyridin-4-yl)propanoic acid
  • 2-Bromothieno[3,2-b]pyridin-7-ol
  • 2-Amino-2-(5-bromothiophen-3-yl)acetic acid
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