Tosyl phenylalanyl chloromethyl ketone
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Names
[ CAS No. ]:
402-71-1
[ Name ]:
Tosyl phenylalanyl chloromethyl ketone
[Synonym ]:
(S)-N-(4-Chloro-3-oxo-1-phenyl-2-butyl)-p-toluenesulfonamide
MFCD00000935
TPCK
Benzenesulfonamide, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl-
N-[(2S)-4-Chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide
Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-
N-(p-Toluenesulfonyl)-L-phenylalanyl Chloromethyl Ketone
L-1-4‘-Tosylamino-2-phenylethyl chloromethyl ketone
Tosyl phenylalanyl chloromethyl ketone
EINECS 206-954-6
N-[(2S)-4-Chloro-3-oxo-1-phenyl-2-butanyl]-4-methylbenzenesulfonamide
Tosyl-L-phenylalanyl-chloromethane
N-p-Tosyl-L-phenylalanine chloromethyl ketone
Benzenesulfonamide, N-((1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-
N-Tosyl-L-phenylalanyl Chloromethyl Ketone
L-1-4′-Tosylamino-2-phenylethyl chloromethyl ketone
N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK)
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
509.9±60.0 °C at 760 mmHg
[ Melting Point ]:
106-108ºC(lit.)
[ Molecular Formula ]:
C17H18ClNO3S
[ Molecular Weight ]:
351.848
[ Flash Point ]:
262.2±32.9 °C
[ Exact Mass ]:
351.069580
[ PSA ]:
71.62000
[ LogP ]:
3.98
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.583
[ Storage condition ]:
−20°C
[ Water Solubility ]:
DMSO: >10 mg/mL stable for several months at 4°C.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XT5613500
- CHEMICAL NAME :
- p-Toluenesulfonamide, N-(alpha-(chloroacetyl)phenethyl)-, (-)-
- CAS REGISTRY NUMBER :
- 402-71-1
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C17-H18-Cl-N-O3-S
- MOLECULAR WEIGHT :
- 351.87
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intrauterine
- DOSE :
- 160 mg/kg
- SEX/DURATION :
- female 2 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 25,954,1974
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H318-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R37/38
[ Safety Phrases ]:
26-36
[ RIDADR ]:
UN 3335
[ WGK Germany ]:
3
[ RTECS ]:
XT5613500
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