Tosyl phenylalanyl chloromethyl ketone

Modify Date: 2025-08-23 18:02:31

Tosyl phenylalanyl chloromethyl ketone structure	Common Name	Tosyl phenylalanyl chloromethyl ketone
	CAS Number	402-71-1	Molecular Weight	351.848
	Density	1.3±0.1 g/cm3	Boiling Point	509.9±60.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₈ClNO₃S	Melting Point	106-108ºC(lit.)
	MSDS	Chinese USA	Flash Point	262.2±32.9 °C
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of Tosyl phenylalanyl chloromethyl ketone

TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium[1].

Name	N-tosyl-L-phenylalanyl chloromethyl ketone
Synonym	More Synonyms

Description	TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer Research Areas >> Inflammation/Immunology
References	[1]. H Stöppler, et al. The serine protease inhibitors TLCK and TPCK react with the RB-binding core of HPV-18 E7 protein and abolish its RB-binding capability. Virology. 1996 Mar 15;217(2):542-53.

Density	1.3±0.1 g/cm3
Boiling Point	509.9±60.0 °C at 760 mmHg
Melting Point	106-108ºC(lit.)
Molecular Formula	C₁₇H₁₈ClNO₃S
Molecular Weight	351.848
Flash Point	262.2±32.9 °C
Exact Mass	351.069580
PSA	71.62000
LogP	3.98
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.583
Storage condition	−20°C
Water Solubility	DMSO: >10 mg/mL stable for several months at 4°C.

Tosyl phenylalanyl chloromethyl ketone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT5613500

CHEMICAL NAME :: p-Toluenesulfonamide, N-(alpha-(chloroacetyl)phenethyl)-, (-)-

CAS REGISTRY NUMBER :: 402-71-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H18-Cl-N-O3-S

MOLECULAR WEIGHT :: 351.87

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 160 mg/kg

SEX/DURATION :: female 2 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 25,954,1974

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R37/38
Safety Phrases	26-36
RIDADR	UN 3335
WGK Germany	3
RTECS	XT5613500

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(S)-N-(4-Chloro-3-oxo-1-phenyl-2-butyl)-p-toluenesulfonamide

MFCD00000935

TPCK

Benzenesulfonamide, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl-

N-[(2S)-4-Chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide

Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-

N-(p-Toluenesulfonyl)-L-phenylalanyl Chloromethyl Ketone

L-1-4‘-Tosylamino-2-phenylethyl chloromethyl ketone

Tosyl phenylalanyl chloromethyl ketone

EINECS 206-954-6

N-[(2S)-4-Chloro-3-oxo-1-phenyl-2-butanyl]-4-methylbenzenesulfonamide

Tosyl-L-phenylalanyl-chloromethane

N-p-Tosyl-L-phenylalanine chloromethyl ketone

Benzenesulfonamide, N-((1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-

N-Tosyl-L-phenylalanyl Chloromethyl Ketone

L-1-4′-Tosylamino-2-phenylethyl chloromethyl ketone

N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK)

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tosyl phenylalanyl chloromethyl ketone
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: TPCK
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tosyl phenylalanyl chloromethyl ketone
Price: ￥388.0/250mg ￥1058.0/1g ￥88.0/25mg ￥248.0/100mg
Purity: 97.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: TPCK
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-chloromethyl (2-phenyl-1-(p-toluenesulphonylamino)ethyl) ketone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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