Tosyl phenylalanyl chloromethyl ketone
Modify Date: 2026-08-02 19:55:58
Tosyl phenylalanyl chloromethyl ketone structure
|
Common Name | Tosyl phenylalanyl chloromethyl ketone | ||
|---|---|---|---|---|
| CAS Number | 402-71-1 | Molecular Weight | 351.848 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 509.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H18ClNO3S | Melting Point | 106-108ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 262.2±32.9 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
Use of Tosyl phenylalanyl chloromethyl ketoneTPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium[1]. |
| Name | N-tosyl-L-phenylalanyl chloromethyl ketone |
|---|---|
| Synonym | More Synonyms |
| Description | TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium[1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 509.9±60.0 °C at 760 mmHg |
| Melting Point | 106-108ºC(lit.) |
| Molecular Formula | C17H18ClNO3S |
| Molecular Weight | 351.848 |
| Flash Point | 262.2±32.9 °C |
| Exact Mass | 351.069580 |
| PSA | 71.62000 |
| LogP | 3.98 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.583 |
| InChIKey | MQUQNUAYKLCRME-INIZCTEOSA-N |
| SMILES | Cc1ccc(S(=O)(=O)NC(Cc2ccccc2)C(=O)CCl)cc1 |
| Storage condition | −20°C |
| Water Solubility | DMSO: >10 mg/mL stable for several months at 4°C. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R37/38 |
| Safety Phrases | 26-36 |
| RIDADR | UN 3335 |
| WGK Germany | 3 |
| RTECS | XT5613500 |
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External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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| (S)-N-(4-Chloro-3-oxo-1-phenyl-2-butyl)-p-toluenesulfonamide |
| MFCD00000935 |
| TPCK |
| N-[(2S)-4-Chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide |
| N-(p-Toluenesulfonyl)-L-phenylalanyl Chloromethyl Ketone |
| L-1-4‘-Tosylamino-2-phenylethyl chloromethyl ketone |
| Tosyl phenylalanyl chloromethyl ketone |
| EINECS 206-954-6 |
| N-[(2S)-4-Chloro-3-oxo-1-phenyl-2-butanyl]-4-methylbenzenesulfonamide |
| Tosyl-L-phenylalanyl-chloromethane |
| N-p-Tosyl-L-phenylalanine chloromethyl ketone |
| N-Tosyl-L-phenylalanyl Chloromethyl Ketone |
| L-1-4′-Tosylamino-2-phenylethyl chloromethyl ketone |
| N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK) |