Tosyl phenylalanyl chloromethyl ketone structure
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Common Name | Tosyl phenylalanyl chloromethyl ketone | ||
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CAS Number | 402-71-1 | Molecular Weight | 351.848 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 509.9±60.0 °C at 760 mmHg | |
Molecular Formula | C17H18ClNO3S | Melting Point | 106-108ºC(lit.) | |
MSDS | Chinese USA | Flash Point | 262.2±32.9 °C | |
Symbol |
GHS05, GHS07 |
Signal Word | Danger |
Use of Tosyl phenylalanyl chloromethyl ketoneTPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium[1]. |
Name | N-tosyl-L-phenylalanyl chloromethyl ketone |
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Synonym | More Synonyms |
Description | TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium[1]. |
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Related Catalog | |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 509.9±60.0 °C at 760 mmHg |
Melting Point | 106-108ºC(lit.) |
Molecular Formula | C17H18ClNO3S |
Molecular Weight | 351.848 |
Flash Point | 262.2±32.9 °C |
Exact Mass | 351.069580 |
PSA | 71.62000 |
LogP | 3.98 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.583 |
Storage condition | −20°C |
Water Solubility | DMSO: >10 mg/mL stable for several months at 4°C. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS05, GHS07 |
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Signal Word | Danger |
Hazard Statements | H315-H318-H335 |
Precautionary Statements | P261-P280-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi: Irritant; |
Risk Phrases | R37/38 |
Safety Phrases | 26-36 |
RIDADR | UN 3335 |
WGK Germany | 3 |
RTECS | XT5613500 |
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EINECS 206-954-6 |
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