(3-beta,5-beta,6-beta)-5,6-Epoxycholestan-3-ol

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Names

[ CAS No. ]:
4025-59-6

[ Name ]:
(3-beta,5-beta,6-beta)-5,6-Epoxycholestan-3-ol

[Synonym ]:
5beta,6beta-Epoxycholestanol
CHOLESTEROL-5BETA,6BETA-EPOXIDE
5,6beta-epoxy-5beta-cholestan-3beta-ol
5BETA,6BETA-EPOXYCHOLESTAN-3BETA-OL
cholestanol,5ß,6ß-epo
cholesterol-5B,6B-epoxide
cholesterolbeta-epoxide

Chemical & Physical Properties

[ Density]:
1.04g/cm3

[ Boiling Point ]:
497.7ºC at 760 mmHg

[ Molecular Formula ]:
C27H46O2

[ Molecular Weight ]:
402.65300

[ Flash Point ]:
200.9ºC

[ Exact Mass ]:
402.35000

[ PSA ]:
32.76000

[ LogP ]:
6.59990

[ Vapour Pressure ]:
5.43E-12mmHg at 25°C

[ Index of Refraction ]:
1.533

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FZ6380000
CHEMICAL NAME :
5-beta-Cholestan-3-beta-ol, 5,6-beta-epoxy-
CAS REGISTRY NUMBER :
4025-59-6
LAST UPDATED :
199410
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C27-H46-O2
MOLECULAR WEIGHT :
402.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,355,1988

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-48/20/21/22

[ Safety Phrases ]:
7-36/37

[ RIDADR ]:
NONH for all modes of transport

Articles

Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles.

J. Lipid Res. 53(4) , 718-25, (2012)

We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent inhibitors of cholesterol-5,6-epoxide hydrolase (ChEH), which led to the...

Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant.

J. Biol. Chem. 279(25) , 26331-8, (2004)

Exposure of the lung to concentrations of ozone found in ambient air is known to cause toxicity to the epithelial cells of the lung. Because of the chemical reactivity of ozone, it likely reacts with ...

Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols.

Cell Biol. Toxicol. 17(2) , 127-37, (2001)

The cytotoxicity of the oxysterols 25-hydroxycholesterol, 7beta-hydroxycholesterol, cholesterol-5alpha,6alphaepoxide, cholesterol-5beta,6beta-epoxide, 19-hydroxycholesterol and 7-ketocholesterol was e...


More Articles

Related Compounds

  • Cholestan-3-ol, 5,6-epoxy-, (3b)-
  • (3β,5α,6α)-(25,26,26,26,27,27,27-2H7)-5,6-Epoxycholestan-3-ol
  • (3β,5β,6β)-(25,26,26,26,27,27,27-2H7)-5,6-Epoxycholestan-3-ol
  • 3-Hydroxy-5,6-dimethylpyridine
  • 3-Quinolinol, 5,6,7,8-tetrahydro- (9CI)
  • 3,4,5,6,7,7-hexamethyloct-4-en-3-ol