Dihydrofolic acid

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Names

[ CAS No. ]:
4033-27-6

[ Name ]:
Dihydrofolic acid

[Synonym ]:
7,8-Dihydropteroyl-L-glutamic acid Dihydropteroyl-L-glutamic acid
DIHYDROFOLIC ACID

Chemical & Physical Properties

[ Density]:
1.69g/cm3

[ Molecular Formula ]:
C19H21N7O6

[ Molecular Weight ]:
443.41300

[ Exact Mass ]:
443.15500

[ PSA ]:
211.89000

[ LogP ]:
0.62870

[ Index of Refraction ]:
1.762

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Folic Acid
  • 2-amino-6[[2'(R)-(benzylamino)-3'-hydroxypropyl]amino]-5-nitro-4(3H)-pyrimidinone
  • 2-amino-6-[[2'(R)-[N-(tert-butoxycarbonyl)-N-benzylamino]-3'-hydroxypropyl]amino]-5-nitro-4(3H)-pyrimidinone
  • N-(4-aminobenzoyl)-L-glutamic acid
  • N-[4-[[2(R)-amino-3-[(2,5-diamino-4(3H)-oxopyrimidin-6-yl)amino]propyl]amino]benzoyl]-L-glutamic acid

DownStream

  • L-5,6,7,8-Tetrahydrofolic acid

Articles

Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly(I:C) nanoplexes.

Mol. Pharm. 11(8) , 2631-9, (2014)

The antifolate drug methotrexate (MTX) can serve as a dual-functional ligand in antitumoral drug delivery, inducing both a folate receptor mediated cellular uptake and an intracellular cytotoxic actio...

A domino effect in antifolate drug action in Escherichia coli.

Nat. Chem. Biol. 4 , 602-8, (2008)

Mass spectrometry technologies for measurement of cellular metabolism are opening new avenues to explore drug activity. Trimethoprim is an antibiotic that inhibits bacterial dihydrofolate reductase (D...

Methotrexate-gelonin conjugate - an inhibitor of MCF-7 cells expressing the dihydrofolate receptor.

Biol. Chem. 395(12) , 1461-6, (2014)

An immunotoxin composed of gelonin, a basic ribosome-inactivating protein, type I of 30 kDa, isolated from the seeds of the Indian plant Gelonium multiflorum and methotrexate (MTX) has been studied as...


More Articles

Related Compounds

  • dihydrofolic acid
  • 10-formyldihydrofolic acid
  • Dihydrofolic acid dihydrate
  • Octanethioic acid S-propyl ester
  • Hexanethioic acid S-decyl ester
  • Thiopropionic acid S-undecyl ester
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 3-Fluoro-4-methoxy-5-(phenylmethoxycarbonylamino)benzoic acid
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide