capsaicin

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Names

[ CAS No. ]:
404-86-4

[ Name ]:
capsaicin

[Synonym ]:
(E)-Capsaicin
8-Methyl-N-vanillyl-trans-6-nonenamide
(E)-8-Methyl-N-vanillyl-6-nonenamide
(6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide
(E)-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide
MFCD00017259
CAPSAICINE
Zostrix
trans-Capsaicin
Qutenza
(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
8-Methyl-N-vanillyl-6-nonenamide
6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-
capsaicin
(E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
6-Nonenimidic acid, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (1Z,6E)-
Transacin
Capsaicin (Natural)
trans-8-methyl-n-vanillyl-6-nonenamide
(6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
N-vanillyl-8-methyl-non-6-enamide
(1Z,6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenimidic acid
Styptysat
N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
Axsain
Capsidol
6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6E)-
8-Methyl-N-vanillyl-trans-6-nonenamide,Capsaicin
8-Methyl-N-vanillyl-6-nonenamide, (E)-
8-methyl N-vanillyl-6-nonenamide
EINECS 206-969-8
Capsaicin, (6E)-

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
469.7±55.0 °C at 760 mmHg

[ Melting Point ]:
62-65 °C(lit.)

[ Molecular Formula ]:
C₁₈H₂₇NO₃

[ Molecular Weight ]:
305.412

[ Flash Point ]:
237.9±31.5 °C

[ Exact Mass ]:
305.199097

[ PSA ]:
58.56000

[ LogP ]:
4.27

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.508

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA8530000

CHEMICAL NAME :: 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-

CAS REGISTRY NUMBER :: 404-86-4

BEILSTEIN REFERENCE NO. :: 2816484

LAST UPDATED :: 199712

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C18-H27-N-O3

MOLECULAR WEIGHT :: 305.46

WISWESSER LINE NOTATION :: 1OR BQ E1MV5U1Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >512 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9000 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >218 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1100 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: >120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2400 mg/kg/2W-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3318 mg/kg/5W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 5 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 48,109,1989 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H317-H319-H334-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R37/38;R41;R42/43

[ Safety Phrases ]:
S22-S26-S28-S36/39-S45

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
RA8530000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2932999099

Precursor & DownStream

Precursor

vanillylamin
TRANS-8-METHYL-6-NONENOYL CHLORIDE
8-METHYLNON-6-ENOIC ACID
(6E)-8-methyl-6-Nonenoic acid, methyl ester
(5-Carboxypentyl) triphenyl phosphonium bromide
(E)-1-hydroxy-6-methylhept-4-ene
Vanillin
CIS 8-METHYLNON-6-ENOIC ACID
6-Hexanolactone
Methyl 6-oxohexanoate

DownStream

Dihydrocapsaicin
methyl 8-methylnonanoate
methyl 7-methyloctanoate
(6E)-8-methyl-6-Nonenoic acid, methyl ester

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Zucapsaicin
Capsaicinoid
Capsaicin-d3
(Z)-CAPSAICIN
Methylcapsaicin
methylcapsaicin
5-(Thiophen-2-yl)-1,2,3,6-tetrahydropyridin-3-ol
prop-2-en-1-yl N-(3-{[(tert-butoxy)carbonyl]amino}-2-hydroxypropyl)-N-methylcarbamate
1-Tert-butyl 4-prop-2-en-1-yl 6-hydroxy-1,4-diazepane-1,4-dicarboxylate
Tert-butyl 3-hydroxy-3-({[(prop-2-en-1-yloxy)carbonyl]amino}methyl)azetidine-1-carboxylate
5-[4-(aminomethyl)-5-ethyl-1H-1,2,3-triazol-1-yl]pentan-2-ol
1-Tert-butyl 1'-prop-2-en-1-yl 4-hydroxy-[4,4'-bipiperidine]-1,1'-dicarboxylate
tert-butyl N-[1-(4-bromophenyl)hex-5-yn-1-yl]carbamate
Tert-butyl 3-[1-(4-bromophenyl)cyclopropyl]azetidine-1-carboxylate
Tert-butyl 5'-bromo-1',2'-dihydrospiro[cyclopentane-1,3'-indole]-1'-carboxylate
[2-(Difluoromethoxy)-3-methylphenyl]methanethiol

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