5'-O-Dimethoxytrityl-deoxythymidine

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Names

[ CAS No. ]:
40615-39-2

[ Name ]:
5'-O-Dimethoxytrityl-deoxythymidine

[Synonym ]:
Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-
5'-O-dimethyltritylthymidine
5'-O-(Bis(4-methoxyphenyl)phenylmethyl)thymidine
EINECS 255-003-1
2,4(1H,3H)-pyrimidinedione, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-glycero-pentofuranosyl]-5-methyl-
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-[(2R,5S)-tetrahydro-5-[1-methoxy-1-(methyldioxy)-2,2,2-triphenylethyl]-2-furanyl]-
1-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-β-D-glycero-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione
MFCD00010113
5′-O-(4,4′-Dimethoxytrityl)thymidine
5'-O-Dimethoxytrityl-deoxythymidine
1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
DMTr-dThd
5‘-O-Dimethoxytrityl-deoxythymidine
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]thymidine
1-{(2R,5S)-5-[1-Methoxy-1-(methylperoxy)-2,2,2-triphenylethyl]tetrahydro-2-furanyl}-5-methyl-2,4(1H,3H)-pyrimidinedione

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Melting Point ]:
114-116 °C (subl.)(lit.)

[ Molecular Formula ]:
C31H32N2O7

[ Molecular Weight ]:
528.596

[ Exact Mass ]:
528.226013

[ PSA ]:
112.01000

[ LogP ]:
6.97

[ Index of Refraction ]:
1.596

[ Storage condition ]:
−20°C

[ Stability ]:
Store in Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4,4'-Dimethoxytrityl chloride
  • Thymidine
  • Pyridine
  • 5'-DMTr-2,2'-anhydrothymidine
  • (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-((2,4-difluorobenzyl)(pyridin-2-yl)amino)ethyl) carbonate
  • [5'-O-(4,4'-dimethoxytrityl)thymidine 3'-(H-phosphonate)](1-)*(CH3CH2)3NH(1+)
  • (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl 2-(azidomethyl)benzoate
  • 4,4'-dimethoxytrityl alcohol
  • 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
  • 2'-Fluoro-5-methylarabinosyluracil

DownStream

  • s4-(2-cyanoethyl)-5'-o-(dimethoxytrityl)-4-thiothymidine
  • Thymidine
  • Alovudine
  • DMT-dT Phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-thymidine-3'-O-succinic acid
  • thymidylyl-(3'-5')-thymidine methyl phosphotriester
  • ((2R,3S)-3-(Tert-Butyldiphenylsilyloxy)-2,3-Dihydrofuran-2-Yl)Methanol
  • 5'-O-(4,4'-DIMETHOXYTRITYL)-2,3'-ANHYDROTHYMIDINE
  • 5'-DMT-N4-Bz-5-Me-dC
  • Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-

Customs

[ HS Code ]: 29349990

Articles

Solid-phase synthesis of polynucleotides. II. Synthesis of polythymidylic acids by the block coupling phosphotriester method.

Nucleic Acids Res. 8(22) , 5473-89, (1980)

Synthesis of two oligothymidylic acids, tridecamer and nonadecamer, is described by a rapid and simple solid-phase method on two kinds of polyacrylamide supports derivatized from commercially availabl...

Synthesis of mixed oligodeoxyribonucleotides following the solid phase method.

Nucleic Acids Res. 10(10) , 3291-301, (1982)

A method for the synthesis of mixed dimers, trimers and oligonucleotides on a solid support using monomeric protected nucleoside phosphochloridites (1a-d) has been developed and the different nucleosi...

Synthesis of 14 C-radiolabeled oligonucleotides with a novel phosphoramidite reagent.

Bioorg. Med. Chem. Lett. 8(9) , 1123-6, (1998)

A novel solid-phase synthesis of 5'-radiolabeled oligonucleotides is described. The labeling reaction is carried out by the phosphoramidite method with the aid of [4,6-di-14C]-5'-dimethoxytritylthymid...


More Articles

Related Compounds

  • 5'-O-(DIMETHOXYTRITYL)-N3/O4-(TOLUOYL)-2-THIOTHYMIDINE
  • (2S,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolane-3-carbaldehyde
  • 5'-O-dimethoxytrityl-N-benzoyldeoxycytidine 3'-p-nitrophenylsuccinate
  • 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-uridine
  • 5'-o-(dimethoxytrityl)-2-(dimethylaminomethylidene-amino)-6-(methoxylamino)purine-2'-deoxyriboside
  • 5'-o-dimethoxytrityl-2'-deoxyguanosine-3'-o]-[(2-meoxy)-(n,n-(i-pr)2)]phosphoramidit
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 2-{2-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]cyclopentyl}acetic acid
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide