PD 146176

Suppliers

Names

[ Name ]:
PD 146176

[Synonym ]:
indole<3,2-c>-1-thiochromen
6,11-Dihydro<benzothiopyrano<6,3-b]indole
6,11-Dihydro-<1>benzothiopyrano-<4,3-b>indol
6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
6,11-Dihydrothiochromeno[4,3-b]indole
6,11-dihydro-5-thia-11-aza-benzo(a)-fluorene
[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-
NAN-190 hydrobromide
6,11-Dihydro-benzo<b>indolo<2,3-d>thiopyran

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
485.4±24.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₁NS

[ Molecular Weight ]:
237.32

[ Flash Point ]:
247.4±22.9 °C

[ Exact Mass ]:
237.061218

[ PSA ]:
41.09000

[ LogP ]:
4.38

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.774

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.

Neoplasia 12 , 254-63, (2010)

The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogene...

An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection.

PLoS ONE 8 , e67828, (2013)

While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotrie...