p-Toluenesulfonyl isocyanate

Suppliers

Names

[ Name ]:
p-Toluenesulfonyl isocyanate

[Synonym ]:
MFCD00002030
p-Toluenesulfonyl isocyanate,AcroSeal
Benzenesulfonamide, N-carbonyl-4-methyl-
p-Toluenesulphonyl isocyanate
4-methylbenzene-1-sulfonyl isocyanate
4-Methylbenzenesulfonyl isocyanate
EINECS 223-810-8
4-Methyl-N-(oxomethylene)benzenesulfonamide
Benzenesulfonyl isocyanate, 4-methyl-
Tosyl isocyanate
p-Toluenesulfonyl isocyanate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
288.8±9.0 °C at 760 mmHg

[ Melting Point ]:
5°C

[ Molecular Formula ]:
C₈H₇NO₃S

[ Molecular Weight ]:
197.211

[ Flash Point ]:
128.5±18.7 °C

[ Exact Mass ]:
197.014664

[ PSA ]:
71.95000

[ LogP ]:
2.44

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.566

[ Water Solubility ]:
reacts

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H331-H334-H335

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P261-P284-P304 + P340 + P312-P305 + P351 + P338-P342 + P311-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R14;R36/37/38;R42

[ Safety Phrases ]:
S26-S28-S30-S28A

[ RIDADR ]:
UN 2206 6.1/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
DB9032000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2929109000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

carbon monoxide
Chloramine-T
N-Chloro-4-methyl-benzenesulfonamide potassium salt,Chloramine T potassium salt,anhydrous
Ethyl [(4-methylphenyl)sulfonyl]carbamate
Methyl tosylcarbamate
Chlorosulfonylisocyanate
trimethyl-(4-methylphenyl)stannane

DownStream

4-METHYL-N-([(4-NITROPHENYL)AMINO]CARBONYL)BENZENESULFONAMIDE
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
N-(3,5-dichloropyridin-2-yl)-4-methylbenzenesulfonamide
4-Toluenesulfonamide
(1-ethenylcyclohexyl) N-(4-methylphenyl)sulfonylcarbamate
Ethyl [(4-methylphenyl)sulfonyl]carbamate
Methyl tosylcarbamate
4-METHYL-N-(2-METHYL-BENZOYL)-BENZENESULFONAMIDE
prop-2-enyl N-(4-methylphenyl)sulfonylcarbamate
Benzenesulfonamide, N-2-cyclopenten-1-yl-4-methyl- (9CI)

Customs

[ HS Code ]: 2929109000

[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Palladium-catalyzed tandem bis-allylation of isocyanates.

Org. Lett. 3(6) , 909-12, (2001)

A tandem bis-allylation of p-toluenesulfonyl isocyanate can be achieved by palladium-catalyzed three-component coupling reaction with allylstannanes and allyl chlorides. A high level of regioselectivi...

Determination of 3-α-hydroxytibolone in human plasma by LC-MS/MS: application for a pharmacokinetic study after administration of a tibolone formulation.

Biomed. Chromatogr. 27(11) , 1457-62, (2013)

A new method was developed for the quantitation of 3-α-hydroxy tibolone, in human plasma, after oral administration of a tablet formulation containing tibolone (2.5 mg). 3-α-Hydroxy tibolone was extra...

Simultaneous determination of diethylene glycol and propylene glycol in pharmaceutical products by HPLC after precolumn derivatization with p-toluenesulfonyl isocyanate.

J. Sep. Sci. 30(16) , 2620-7, (2007)

A simple and reliable HPLC method was developed for the simultaneous quantitative analysis of diethylene glycol (DEG) and propylene glycol (PG) in pharmaceutical products by precolumn derivatization. ...