Nipecotamide

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Names

[ Name ]:
Nipecotamide

[Synonym ]:
piperidine-3-carboxamide
nipecotinamide
3-Piperidinecarboxamide
3-Piperidinecarboxamide,(S)
piperidine-3-carboxylic acid amide
3-Carbamoylpiperidine 3-Piperidinecarboxamide
Nipecotamide
nipecotic acid amide
dihydronicotinamide
3-carboxamidepiperidine
EINECS 223-962-5
HEXAHYDRONICOTINAMIDE
MFCD00005993

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
311.7±31.0 °C at 760 mmHg

[ Melting Point ]:
103-106 °C(lit.)

[ Molecular Formula ]:
C₆H₁₂N₂O

[ Molecular Weight ]:
128.172

[ Flash Point ]:
142.3±24.8 °C

[ Exact Mass ]:
128.094955

[ PSA ]:
55.12000

[ LogP ]:
-0.99

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.483

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Nicotinamide
pyridine-3-carboxamide,hydrochloride

DownStream

1-Boc-3-Carbamoylpiperidine
tert-butyl 3-(thiocarbamoyl)piperidine-1-carboxylate
3-PIPERIDINAMINE HYDROCHLORIDE
1-Boc-4-(3-carbamoylpiperidin-1-ylmethyl)piperidine
(1-Benzylpiperidin-3-yl)methanamine
tert-Butyl 3-(aminomethyl)piperidine-1-carboxylate
3-Aminomethyl piperidine
1-(4-fluoro-2-nitrophenyl)piperidine-3-carboxamide
2-(4-(3-Carbamoylpiperidino)butoxy)bibenzyl
(3S)-3-Piperidinecarboxamide

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effects of sodium n-dipropylacetate, muscimol hydrobromide and (R,S) nipecotic acid amide on isolation-induced aggressive behavior in mice.

Psychopharmacology 70(3) , 287-90, (1980)

An inhibitor of GABA-T (sodium n-dipropylacetate), a GABA agonist (muscimol hydrobromide) and an inhibitor of GABA uptake (R,S) nipecotic acid amide were administered to DBA/2 isolated aggressive mice...

Gabaergic modulation of mouse-killing in the rat.

Psychopharmacology 83(4) , 367-72, (1984)

When GABA-potentiating compounds were administered IP to rats with prior experience of mouse-killing behaviour, a reduction of killing was observed with gamma-vinyl GABA (200 and 400 mg/kg) and nipeco...

Relationships between the chemical constitution of carbamoylpiperidines and related compounds, and their inhibition of ADP-induced human blood platelet aggregation.

Thromb. Res. 22(5-6) , 665-80, (1981)

A-1 Nipecotamide
A-4 Nipecotamide
(R)-NIPECOTAMIDE
ethyl nipecotamide
methyl nipecotamide
1-N-Cbz-Nipecotamide
2-((6-(hydroxymethyl)-9-methyl-2-(p-tolyl)-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)-N-(3-(methylthio)phenyl)acetamide
2-((2-(2-fluorophenyl)-6-(hydroxymethyl)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)-N-(2-methoxyphenyl)acetamide
2-((2-(2-fluorophenyl)-6-(hydroxymethyl)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)-N-(3-methoxyphenyl)acetamide
2-((2-(2-fluorophenyl)-6-(hydroxymethyl)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)-N-(4-methoxyphenyl)acetamide
N-(2-chlorophenyl)-2-((2-(2-fluorophenyl)-6-(hydroxymethyl)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)acetamide
N-(4-ethoxyphenyl)-2-((2-(2-fluorophenyl)-6-(hydroxymethyl)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)acetamide
N-(2-fluorophenyl)-2-((2-(2-fluorophenyl)-6-(hydroxymethyl)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)acetamide
N-(4-fluorophenyl)-2-((2-(2-fluorophenyl)-6-(hydroxymethyl)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)acetamide
N-(4-ethylphenyl)-2-((2-(2-fluorophenyl)-6-(hydroxymethyl)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)acetamide
N-(2-ethylphenyl)-2-((2-(2-fluorophenyl)-6-(hydroxymethyl)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-4-yl)thio)acetamide

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