2-Methyl-L-proline

Names

[ Name ]:
2-Methyl-L-proline

[Synonym ]:
MFCD01318647
α-Methyl-L-proline
L-Proline, 2-methyl-
2-Methyl-L-proline
(2S)-2-methylpyrrolidine-2-carboxylic acid,hydrochloride
(S)-2-Methyl proline

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
241.9±33.0 °C at 760 mmHg

[ Melting Point ]:
310 °C

[ Molecular Formula ]:
C₆H₁₁NO₂

[ Molecular Weight ]:
129.157

[ Flash Point ]:
100.1±25.4 °C

[ Exact Mass ]:
129.078979

[ PSA ]:
49.33000

[ LogP ]:
-0.03

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.475

[ Storage condition ]:
-15°C

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(2S)-2-Methyl-2-Pyrrolidinecarboxamide
H-DL-(αMe)Pro-NH2
(2R,5S)-2-tert-butyl-5-methyl-1-aza-3-oxabicyclo(3.3.0)octan-4-one
5-methyl-1-oxido-3,4-dihydro-2H-pyrrol-1-ium
1-[(Benzyloxy)carbonyl]-2-methyl-L-proline
benzyl (S)-2-carbamoyl-2-Methylpyrrolidine-1-carboxylate
(S)-2-Methyl-2-pyrrolidinecarboxylicacid
(1'R,2S,2'S,5'R)-1-[(2-isopropyl-5-methylcyclohexyl)oxymethoxy]-2-methyl-2-pyrrolidinecarbonitrile

DownStream

L-Proline, 1,2-dimethyl-
Methyl 2-methyl-L-prolinate
(2S)-2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
(S)-1-(((benzyloxy)carbonyl)glycyl)-2-methylpyrrolidine-2-carboxylicacid
1-[(Benzyloxy)carbonyl]-2-methyl-L-proline

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effects of ring contraction on the conformational preferences of α-substituted proline analogs.

Biopolymers 98(2) , 98-110, (2012)

The structural consequences derived from the incorporation of either a methyl or a phenyl group at the α carbon of proline were recently investigated by quantum mechanical calculations (J Org Chem 200...

Beta-turns induced in bradykinin by (S)-alpha-methylproline.

FEBS Lett. 297(3) , 216-20, (1992)

The ability of (S)-alpha-methylproline (alpha-MePro) to stabilise reverse-turn conformations in the peptide hormone bradykinin (BK = Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9) has been investigated...

alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model.

J. Med. Chem. 30(3) , 536-41, (1987)

A structure-activity analysis of peptides containing backbone C alpha-methyl modification at the P4 site of the angiotensinogen sequence led to the discovery of potent renin inhibitors with apparent i...

2-Methyl-L-proline
N-BOC-2-METHYL-L-PROLINE
2-methyl-L-proline hydrobromide
2-Methyl-L-proline hydrochloride
(4R)-4-Hydroxy-2-methyl-L-proline
(4S)-4-Hydroxy-2-methyl-L-proline
ethyl 4-(1-methyl-2,4-dioxo-6,7,8,9a,10,10a-hexahydro-4aH-purino[7,8-a]pyrimidin-9-yl)benzoate
1,3-Bis(1,1-dimethylethyl) 2-[5-(trifluoromethyl)-3-pyridinyl]imidodicarbonate
3-(2,5-Dimethoxyphenyl)-3-methylbutan-1-amine
Tert-butyl (1-(3-aminopyridin-4-yl)-6-methylpiperidin-3-yl)carbamate
6-(2-Methoxyphenyl)-4-methyl-4a,7,8,9a-tetrahydropurino[7,8-a]imidazole-1,3-dione
4-(4-Bromophenyl)-1-isopropyl-1H-pyrazole
3-(3,4-Dichlorophenyl)-3-methylbutan-1-amine
2-(3-hydroxypropyl)-4,7,8-trimethyl-9aH-purino[8,7-b][1,3]oxazol-9-ium-1,3-dione
3-(4-chlorophenyl)-2,5-dimethyl-6-(3-methylbutyl)-2,3,3a,4-tetrahydro-1H-pyrazolo[1,5-a]pyrimidin-7-one
2-[8-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-1,3-dimethyl-2,6-dioxo-5H-purin-7-ium-7-yl]acetamide

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