2-Methyl-L-proline
2-Methyl-L-proline structure
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Common Name | 2-Methyl-L-proline | ||
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| CAS Number | 42856-71-3 | Molecular Weight | 129.157 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 241.9±33.0 °C at 760 mmHg | |
| Molecular Formula | C6H11NO2 | Melting Point | 310 °C | |
| MSDS | Chinese USA | Flash Point | 100.1±25.4 °C | |
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Effects of ring contraction on the conformational preferences of α-substituted proline analogs.
Biopolymers 98(2) , 98-110, (2012) The structural consequences derived from the incorporation of either a methyl or a phenyl group at the α carbon of proline were recently investigated by quantum mechanical calculations (J Org Chem 2008, 73, 3418). In this work, the effect produced by contract... |
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Beta-turns induced in bradykinin by (S)-alpha-methylproline.
FEBS Lett. 297(3) , 216-20, (1992) The ability of (S)-alpha-methylproline (alpha-MePro) to stabilise reverse-turn conformations in the peptide hormone bradykinin (BK = Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9) has been investigated. Two BK analogues containing alpha-MePro at position 3 or ... |
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alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model.
J. Med. Chem. 30(3) , 536-41, (1987) A structure-activity analysis of peptides containing backbone C alpha-methyl modification at the P4 site of the angiotensinogen sequence led to the discovery of potent renin inhibitors with apparent in vitro metabolic stability. Boc-alpha-MePro-Phe-His-Leu ps... |
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Alpha-methyl-proline restores normal levels of bone collagen Type I synthesis in ovariectomized rats.
Life Sci. 57(24) , 2245-52, (1995) Collagen type I is the major protein of bone matrix and significantly reduced in osteoporosis. We tested the effect of alpha - methyl - proline on collagen synthesis in the model of the ovariectomized rat. Collagen synthesis was studied at the transcriptional... |
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Conformational analysis of homochiral and heterochiral diprolines as beta-turn-forming peptidomimetics: unsubstituted and substituted models.
J. Pept. Res. 50(1) , 1-13, (1997) The effect of replacing one of the proline residues in either unsubstituted homochiral or heterochiral diproline segments with either a 2- or a 3-substituted prolyl residue on the allowed conformational of the diproline template has been examined. In heteroch... |
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Is the backbone conformation of C(alpha)-methyl proline restricted to a single region?
Chemistry 15(32) , 8015-25, (2009) C(alpha)-methyl-L-proline, or L-(alphaMe)Pro, is probably the most conformationally constrained alpha-amino acid. In particular, its omega and phi torsion angles are restricted to about 180 and -60 degrees, respectively, and only three ranges of values are th... |
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C(alpha)-methyl proline: a unique example of split personality.
Biopolymers 89(5) , 465-70, (2008) Methylation at the C(alpha)-position of a Pro residue was expected to lock the preceding tertiary amide (omega) torsion angle of the resulting (alphaMe)Pro to the trans disposition and to restrict the phi,psi surface to the single region where the 3(10)/alpha... |