2-Fluorobenzyl bromide

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Names

[ CAS No. ]:
446-48-0

[ Name ]:
2-Fluorobenzyl bromide

[Synonym ]:
α-Bromo-o-fluorotoluene
FR B1E
EINECS 207-169-1
o-Fluorobenzyl bromide
α-Bromo-2-fluorotoluene
2-Fluorobenzyl bromide
Benzene, 1-(bromomethyl)-2-fluoro-
MFCD00000324
1-(Bromomethyl)-2-fluorobenzene

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
200.2±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H6BrF

[ Molecular Weight ]:
189.025

[ Flash Point ]:
82.8±0.0 °C

[ Exact Mass ]:
187.963684

[ LogP ]:
2.97

[ Vapour Pressure ]:
0.5±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.544

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S23-S26-S27-S36/37/39-S45

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Fluorotoluene
  • 2-Fluorobenzaldehyde
  • o-fluorobenzyl alcohol
  • Hydrogen bromide
  • benzene
  • Cyanogen bromide
  • (2-fluoro-benzyl)-(4-fluoro-benzyl)-methyl-amine
  • N-Benzyl-2-fluoro-N-Methylbenzylamine
  • Bromine

DownStream

  • 2-Fluorophenylacetonitrile
  • 1-[(2-FLUOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE
  • 1-Benzyl-2-fluorobenzene
  • 2-Fluorobenzylboronic acid pinacol ester
  • 2-Fluorobenzaldehyde
  • o-fluorobenzyl alcohol
  • 1-(2-Fluorophenyl)methanamine
  • 2-(2-Fluorophenyl)ethanamine
  • 1-(2-Fluoro-benzyl)-1H-indole-3-carbaldehyde
  • 2-Fluorotoluene

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis of prasugrel. SUN Z-G, et al

Chin. J. Pharm. 4 , 006, (2009)

Synthesis and anticonvulsant activity of N-benzylpyrrolo[2,3-d]-, -pyrazolo[3,4-d]-, and -triazolo[4,5-d]pyrimidines: imidazole ring-modified analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine.

J. Med. Chem. 38(19) , 3884-8, (1995)

Analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine (1) containing isosteric replacements of the imidazole ring atoms were synthesized and tested for anticonvulsant activity. The pyrrolo[2,3-d]-...

Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.

Bioorg. Med. Chem. Lett. 12(3) , 399-402, (2002)

Initial SAR studies on 1-aminomethyl-2-aryl-3-cyano-pyrrolo[1,2-a]pyrimid-7-one-6-carboxylates as human GnRH receptor antagonists were discussed. 2-(2-Methylaminoethyl)pyridine was discovered to be a ...


More Articles

Related Compounds

  • 6-bromo-2-fluorobenzyl bromide
  • 4-Cyano-2-fluorobenzyl Bromide
  • 5-cyano-2-fluorobenzyl bromide
  • 3-Bromo-2-fluorobenzyl bromide
  • 4-Bromo-2-fluorobenzyl bromide
  • 4-amino-2-fluorobenzyl bromide
  • 2-(3-Amino-1-benzylpiperidin-3-yl)acetamide
  • (1-ethyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl)methanamine
  • N-(2-(3-((3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl)methyl)piperidin-1-yl)-2-oxoethyl)-N-methylmethanesulfonamide
  • 2-[(5-Methoxy-2-nitrophenyl)amino]propanoic acid
  • 2-(3-Amino-1-benzyl-5-methylpyrrolidin-3-yl)acetic acid
  • 2-(3-Amino-1-benzyl-2-methylpyrrolidin-3-yl)acetic acid
  • 1-(4-Fluoro-3-methoxyphenyl)-2-(methylamino)ethan-1-ol
  • 2-(But-3-yn-1-yl)-1-methoxy-3-methylbenzene
  • 1-(2-Methylpyridin-4-yl)cyclohexan-1-amine
  • [1-(4-Methylpyridin-3-yl)cyclopentyl]methanamine
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