Angiotensin II acetate salt

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Names

[ Name ]:
Angiotensin II acetate salt

[Synonym ]:
Phenylalanine, α-aspartyl-N-(diaminomethylene)ornithylvalyltyrosylisoleucylhistidylprolyl-
α-Aspartylarginylvalyltyrosylisoleucylhistidylprolylphenylalanine
phenylalanine, α-aspartylarginylvalyltyrosylisoleucylhistidylprolyl-
α-aspartyl-N-(diaminomethylidene)ornithylvalyltyrosylisoleucylhistidylprolylphenylalanine
α-Aspartyl-N-(diaminomethylene)ornithylvalyltyrosylisoleucylhistidylprolylphenylalanine
Angiotensin II
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE
Angiotensin II human

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
809.08°C (rough estimate)

[ Molecular Formula ]:
C₅₀H₇₁N₁₃O₁₂

[ Molecular Weight ]:
1046.179

[ Exact Mass ]:
1045.534546

[ PSA ]:
406.34000

[ LogP ]:
2.34

[ Index of Refraction ]:
1.664

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BW2165000

CHEMICAL NAME :: Angiotensin II, 5-L-isoleucine-

CAS REGISTRY NUMBER :: 4474-91-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C50-H71-N13-O12

MOLECULAR WEIGHT :: 1046.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 119 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6109,1990

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BW2165000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats.

Can. J. Cardiol. 30(12) , 1700-5, (2014)

Recent evidence suggests that an elevated plasma trimethylamine N-oxide (TMAO) level is associated with an increased risk of adverse cardiovascular events in humans; however, the mechanism is not clea...

IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.

J. Cereb. Blood Flow Metab. 34(12) , 1887-97, (2014)

Aging impairs autoregulatory protection in the brain, exacerbating hypertension-induced cerebromicrovascular injury, neuroinflammation, and development of vascular cognitive impairment. Despite the im...

Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension.

Clin. Sci. 127(1) , 57-63, (2014)

The somatic isozyme of ACE (angiotensin I-converting enzyme) comprises two distinct zinc-dependent catalytic domains with different substrate specificities for angiotensin I (cleaved selectively by th...