Angiotensin II acetate salt

Modify Date: 2024-01-02 03:32:14

Angiotensin II acetate salt Structure
Angiotensin II acetate salt structure
 Common Name Angiotensin II acetate salt
CAS Number 4474-91-3 Molecular Weight 1046.179
Density 1.4±0.1 g/cm3 Boiling Point 809.08°C (rough estimate)
Molecular Formula C50H71N13O12 Melting Point N/A
MSDS USA Flash Point N/A

 Use of Angiotensin II acetate salt


Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.

 Names

Name Angiotensin Ⅱ, human
Synonym More Synonyms

 Angiotensin II acetate salt Biological Activity

Description Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.
Related Catalog
Target

Angiotensin receptor (AT receptor)[1]

In Vitro Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function[1]. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2]. At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT1 and AT2). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors[3].
In Vivo To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[3].
Animal Admin Mice[3] (129×C57BL/6) F1 mice lacking AT1A receptors for Angiotensin II are used. The mice are fed 10 gm/day gelled 0.25% NaCl diet that contains all nutrients and water. After 1 week of baseline collections, the animals are implanted with osmotic minipumps infusing Angiotensin II and are returned to the metabolic cage for 5 more days. Urinary sodium content is determined by using an IL943 Automatic Flame photometer. After 28 days of Angiotensin II infusion, hearts are harvested, weighed, fixed in formalin, sectioned, and stained with Masson trichrome. All of the tissues are examined by a pathologist (P.R.) without knowledge of genotypes.
References

[1]. de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.

[2]. Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.

[3]. Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 809.08°C (rough estimate)
Molecular Formula C50H71N13O12
Molecular Weight 1046.179
Exact Mass 1045.534546
PSA 406.34000
LogP 2.34
Index of Refraction 1.664
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BW2165000
CHEMICAL NAME :
Angiotensin II, 5-L-isoleucine-
CAS REGISTRY NUMBER :
4474-91-3
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C50-H71-N13-O12
MOLECULAR WEIGHT :
1046.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
119 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6109,1990

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS BW2165000

 Articles190

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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.

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Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension.

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The somatic isozyme of ACE (angiotensin I-converting enzyme) comprises two distinct zinc-dependent catalytic domains with different substrate specificities for angiotensin I (cleaved selectively by th...

 Synonyms

Phenylalanine, α-aspartyl-N-(diaminomethylene)ornithylvalyltyrosylisoleucylhistidylprolyl-
α-Aspartylarginylvalyltyrosylisoleucylhistidylprolylphenylalanine
phenylalanine, α-aspartylarginylvalyltyrosylisoleucylhistidylprolyl-
α-aspartyl-N-(diaminomethylidene)ornithylvalyltyrosylisoleucylhistidylprolylphenylalanine
α-Aspartyl-N-(diaminomethylene)ornithylvalyltyrosylisoleucylhistidylprolylphenylalanine
Angiotensin II
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE
Angiotensin II human
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