Coenzyme M

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Names

[ CAS No. ]:
45127-11-5

[ Name ]:
Coenzyme M

[Synonym ]:
Ethanesulfonic acid, 2,2'-dithiobis-
2,2'-Dithiodiethanesulfonic acid
2,2'-dithiobisethanesulfonic acid
Ethanesulfonic acid,2,2'-dithiobis
2,2'-Disulfanediyldiethanesulfonic acid
Coenzyme

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Molecular Formula ]:
C4H10O6S4

[ Molecular Weight ]:
282.379

[ Exact Mass ]:
281.936005

[ PSA ]:
176.10000

[ LogP ]:
-1.83

[ Index of Refraction ]:
1.637

Safety Information

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • MESNA
  • Sodium 2-bromoethanesulfonate
  • 2-Mercaptoethanesulfonic acid

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of human aminopeptidase N.

Cancer Chemother. Pharmacol. 67(2) , 381-91, (2011)

Previous studies from our laboratory have identified a role for gamma-glutamyl transpeptidase (GGT) in BNP7787 (disodium 2,2'-dithio-bis ethane sulfonate, dimesna, Tavocept™)-mediated cisplatin nephro...

Phase II randomized study of dose-dense docetaxel and cisplatin every 2 weeks with pegfilgrastim and darbepoetin alfa with and without the chemoprotector BNP7787 in patients with advanced non-small cell lung cancer (CALGB 30303).

J. Thorac. Oncol. 3(10) , 1159-65, (2008)

We investigated dose-dense docetaxel and cisplatin in patients with measurable non-small cell lung cancer in a randomized phase II study without [A] or with [B] a putative chemoprotective agent, BNP77...

New approaches to drug discovery and development: a mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent.

Cancer Chemother. Pharmacol. 52 Suppl 1 , S3-15, (2003)

Any approach applied to drug discovery and development by the medical community and pharmaceutical industry has a direct impact on the future availability of improved, novel, and curative therapies fo...


More Articles

Related Compounds

  • coenzyme M
  • ethyl coenzyme M
  • CH3-S-Coenzyme M
  • methyl coenzyme M
  • coenzyme M sodium salt
  • coenzyme M sodium salt
  • 1-(4-Hydroxypiperidin-4-YL)propan-2-one
  • 5-Bromo-6-(cyclopropylmethoxy)-3-(ethylsulfonyl)-1-methyl-1h-indazole
  • 2-{Ethyl[6-(2-methoxyethyl)pyrimidin-4-yl]amino}ethan-1-ol
  • 2-[4-(2-Bromo-6-fluorophenyl)phenyl]acetonitrile
  • 6-Bromo-2,3-bis(2-methoxyethyl)isoindolin-1-one
  • tert-Butyl (S)-3-(2-bromo-4-(methoxycarbonyl) phenoxy) pyrrolidine-1-carboxylate
  • 3,9-Di-tert-butyl 6-ethyl 7-oxo-3,9-diazabicyclo[3.3.1]nonane-3,6,9-tricarboxylate
  • Benzyl 5-((benzyloxy)imino)-2-((tert-butoxycarbonyl)amino)-6-chlorohexanoate
  • (3-Bromophenyl)(5-chloropyridin-2-yl)methanone
  • 2-Bromo-3-fluoro-4-iodo-6-methylpyridine